Efficacy and Safety of Intravenous Tranexamic Acid on Perioperative Blood Loss in Spinal Metastasis Decompressive Surgery: A Double-blinded, Randomized, Placebo-controlled Trial
Phase 4
Recruiting
- Conditions
- Spinal metastasis occurs in approximately 15.67% of all cancer cases, with 1 in 10 of these patients experiencing nerve compression. This compression leads to sensory loss, muscle weakness, and loss of bowel and bladder control, significantly impacting patients'
- Registration Number
- TCTR20240608003
- Lead Sponsor
- Department Orthopaedic Surgery, Mahidol University Faculty of Medicine Siriraj Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 108
Inclusion Criteria
Patients with metastatic spinal cord compression at the Thoracolumbar spine who have undergone laminectomy and instrumentation surgery.
Exclusion Criteria
1. Patients who have not stopped antiplatelet or anticoagulant medication prior to surgery.
2. Presence of coagulopathy.
3. Platelet level less than 50,000
4. History of allergy to Tranexamic acid or contraindications to its use.
5. History of venous thromboembolic events.
6. Serum creatinine level more than and equal 2.5
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method