Accurate Estimation of Sodium Intake with Limited Patient Burde

Recruiting

Conditions: chronic kidney failure
high blood pressure
10011082
10038430
10057166

Registration Number: NL-OMON54047

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

Healthy individuals: 18-80 years; eGFR above 60 ml/min/1.73m2 without
albuminuria.

CKD patients: 18-80 years; eGFR 15-60 and/or albuminuria (albumine >30 mg/24h
or albumine-creatinine ratio >3 mg/mmol).

Exclusion Criteria

Healthy individuals: albuminuria; BMI > 30 kg/m2; office blood pressure >
140/90 mmHg; history of diabetes mellitus, hypertension, kidney disease,
cardiovascular disease, restrictive dietary habits, eating disorders and/or
food allergies; use of systemic glucocorticoids, antihypertensive and/or
antidiabetic medication.

CKD patients: office blood pressure > 180/100 mmHg; suffering of acute kidney
injury; changes in antihypertensive medication in the last 2 months; use of
systemic glucocorticoids; dialysis treatment or expected initiation of dialysis
within 3 months of screening; a history of restrictive dietary habits, an
eating disorder or food allergies

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main outcome of this study is the difference between measured dietary Na+<br /><br>and K+ intake and estimated Na+ and K+ intake, using multiple estimation<br /><br>methods.<br /><br><br /><br>We will compare the abovementioned outcomes in healthy individuals and<br /><br>individuals with chronic kidney disease.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We will compare methods for dietary Na+/K+ ratio estimation: single or repeated<br /><br>24-hour measurement and single or repeated spot urine measurement. We will<br /><br>investigate the potential value of the urine Na+/K+ ratio as compared to<br /><br>separate urine Na+ and K+ measurements.<br /><br><br /><br>We will investigate the effects of correcting 24-hour Na+ and K+ excretion for<br /><br>24-hour aldosterone and cortisol excretion.<br /><br><br /><br>We will compare the abovementioned outcomes in healthy individuals and<br /><br>individuals with chronic kidney disease.</p><br>