Role of brown fat and skeletal muscle in post-prandial clearance of triglycerides during and after cold exposure

Recruiting

Conditions: Hypertriglyceridaemia
too much lipids in the bloodstream
10052547
10013317

Registration Number: NL-OMON47578

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 17

Inclusion Criteria

- Signed informed consent
- Caucasian
- Aged 20-50 years at the start of the study
- Body mass index (BMI) 20-30 kg/m2
- Stable dietary habits (no weight loss or gain of more than 5 kg in the past 3 months
- Stable sedentary lifestyle (not more than 2 hours of sports per week)

Exclusion Criteria

- Use of cholesterol or lipid-lowering medication
- Active diseases (cardiovascular, diabetes mellitus, liver, kidney, cancer or other)
- Participation in earlier research that included PET/CT scanning for detection of brown adipose tissue activity in the last 3 months
- Alcohol consumption of >2 servings per day
- Smoking in the past 6 months
- Haemoglobine content <8.4 mmol/L

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Meal test: post-prandial metabolism of triglycerides, cholesterol and<br /><br>lipoprotein.<br /><br>PET/CT: Presence and activity of brown adipose tissue, as measured by PET/CT<br /><br>scan<br /><br>Muscle biopsy: cell culture, the role of skeletal muscle on the post-prandial<br /><br>clearance of triglcyerides<br /><br>Energy expenditure: measured by indirect calorimetry<br /><br><br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Skin temperature: measured via iButtons on different places on the skin<br /><br>Core temperature: measured via a sensor in the gastro-intestinal tract</p><br>