Could prone positioning increase lung function for patients with severe COVID-19 infection?

Not Applicable

Completed

• Conditions: Respiratory function in patients with respiratory failure due to COVID-19 infection; Infections and Infestations

• Registration Number: ISRCTN54917435
• Lead Sponsor: ppsala County Council

Brief Summary

2021 Results article in https://pubmed.ncbi.nlm.nih.gov/34127046/ (added 13/08/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-06-15
• Study Completion: 2021-06-25
• Last Update Posted: 9 January 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

1. Age 18 year or older
2. Admission to a hospital with confirmed or strongly suspected COVID-19 infection
3. Hypoxic respiratory failure defined as a PaO2/FiO2 ratio = 20 kPa (150 mmHg) and/or a FiO2 of = 0.5 to reach a SpO2 of 94% for more than 1 hour
4. Oxygen supplementation (ongoing or planned) with high flow nasal cannuale or noninvasive ventilating support

Exclusion Criteria

1. Severe nasal obstruction or other contraindication to high flow nasal cannulae
2. Patient unable to lay prone or in the face forward position
3. Immediate need for intubation
4. Severe and/or uncontrolled hemodynamic instability
5. Previous intubation for COVID-19 pneumonia (i.e. step down patients)
6. Pregnancy
7. Known terminal illness with life expectancy less than 1 year
8. Decision not to intubate
9. Inability to understand oral or written study information and/or to cooperate with instructions necessary to complete the allocated intervention
10. Inability to understand oral or written study information

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of intubation for mechanical ventilation support, recorded in EHR at inclusion and once if applied. Timeframe 30 days after inclusion.