Three-day vs five-day oral prednisolone for acute exacerbation in chronic obstructive pulmonary disease

Phase 3

• Conditions: lactation; We exclude patients who have a history of asthma, ischemic heart disease, radiological diagnosis of pneumonia, congestive heart failure or other lung diseases, history of any cancer disease, pregnancy; history of asthma; ischemic heart disease; radiological diagnosis of pneumonia

• Registration Number: TCTR20200327002
• Lead Sponsor: khon kaen hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-27
• Study Completion: 2020-11-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Thai patients who were 20-year-old or older who diagnosed acute exacerbation of COPD and history of the ratio of FEV1 to forced vital capacity (FVC) lower than 70% as evaluated by postbronchodilator spirometry, history of FEV1 lower than 80% as evaluated by postbronchodilator spirometry and smoking history of 10 pack-years or more.

Exclusion Criteria

We exclude patients who have a history of asthma, ischemic heart disease, radiological diagnosis of pneumonia, congestive heart failure or other lung diseases, history of any cancer disease, pregnancy or lactation, need continuous immunosuppressive (e.g. prednisolone, dexamethasone, methylprednisolone, IVIG), need a ventilator, inability to follow up and inability to give written informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
relapse of acute exacerbation in chronic obstructive pulmonary disease 1 month yes or no of relapse

Secondary Outcome Measures

Name	Time	Method
oxygen saturation 1 month pulse oxymeter,failure treatment 1 month count number,symptom's free days 1 month count number,FEV1 1 month spirometer