Efficacy of once weekly thyroxine treatment for poorly controlled hypothyroid patients
Phase 4
Completed
- Conditions
- Health Condition 1: E039- Hypothyroidism, unspecifiedHealth Condition 2: null- Patients with hypothyroidism and requiring a more than ususal (1.7 mcg/kg/day) thyroxine with poor control. (TSH mor than 10mcIu/ml)
- Registration Number
- CTRI/2017/06/008855
- Lead Sponsor
- State board of Medical Research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 34
Inclusion Criteria
1) Patients with TSH >10 mcIU/ml inspite of a Thyroxine dose more than 1.7 mcg/kg/day.
2)Those requiring a thyroxine dose more than 3mcg/kg body weight/day.
Exclusion Criteria
1) Patients with critical Illness
2) Patients unwilling for the study.
3) Patients with known gastrointestinal malabsorptivedisrorders.
4)Patients with known structural, ischemic or rhythm disease of the heart.
5) Patients on medications known to decrease thyroxine absorption or hasten metabolism.
6) Patients accepting non-compliance to medications missing even one dose in last 6 weeks.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decrease in TSH from baseline.Timepoint: 6 weeks and 12 weeks.
- Secondary Outcome Measures
Name Time Method Percentage of patients achieving TSH less than 5 mcIU/mlTimepoint: 6 weeks, 12 weeks