Immunological factors of pain and infection in patients with burns

Completed

• Conditions: infectie en pijn bij brandwonden; Pain and infection in burns; 10004018; 10014982

• Registration Number: NL-OMON39434
• Lead Sponsor: Vereniging Samenwerkende Brandwondencentra Nederland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 55

Inclusion Criteria

>= 5% total burned surface area
Able to understand research information and able to give informed consent

Exclusion Criteria

< 5% total burned surface area
Not able to understand Dutch

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Main objectives are to analyse cytokines (IL-6, IL-10, TNFalpha), cortisol,<br /><br>chemokines and MBL in residual blood samples. Levels of cytokines and cortisol<br /><br>will be correlated with self-reported pain and psychological problems<br /><br>(peri-traumatic reaction to accident, depression, and anxiety) and controlled<br /><br>for infection. MBL levels and genotypes will be examined in relation to<br /><br>bacterial presence and wound healing. Levels of cytokines in eschar will<br /><br>examined and correlated to pain scores.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>We want to explore a possible relationship between cortisol on day 1 and the<br /><br>subjective peri-traumatic reaction to the burn event.</p><br>