ITMCTR2200006651尚未招募1 期
Study on the intestinal mechanism of Jianpi Qushi He Luo Fang in regulating intestinal bacteria AHR agonist host immunity in treating IM
试验速览
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional study
入排标准
- 年龄范围
- 18 至 70（—）
- 性别
- All
入选标准
- •(1) Kidney biopsy pathological diagnosis of MN, or positive anti-PLA2R antibody;
- •(2) Meet the diagnostic criteria of spleen deficiency syndrome;
- •(3) The course of disease is longer than 6 months;
- •(4) Urine protein was quantified at 3-8g /24h;
- •(5) Blood pressure can be effectively controlled at =140/90mmHg;
- •(6) eGFR 45 ml/min or more,
- •(7) 18-70 years old, no gender limitation;
- •(8) Antibiotics and probiotics have not been used in the past one month;
- •(9) Body mass index (BMI) between 18.5 and 28.5 kg/m2;
- •(10) Signed informed consent.
排除标准
- •(1) Exclude secondary membranous nephropathy (including tumor-related membranous nephropathy, hepatitis B-related membranous nephropathy, lupus membranous nephropathy, drug and toxin-related membranous nephropathy);
- •(2) the eGFR < 45 ml/min.
- •(3) hormone and/or immunosuppressant treatment within 6 months;
- •(4) women who have pregnancy plan, pregnancy or breast-feeding period;
- •(5) complicated with serious diseases of heart, brain, liver and hematopoietic system, or other serious diseases affecting their survival;
- •(6) Metabolic diseases such as obesity and diabetes;
- •(7) History of gastrointestinal diseases or gastrointestinal surgery (except appendectomy);
- •(8) Rheumatoid arthritis, sjogren's syndrome and other autoimmune diseases;
- •(9) Antibiotics and probiotics were used within the past one month.
研究者
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