Effects of Palmar Cooling on the Human Immune System
- Conditions
- Human Immune Response
- Registration Number
- NCT07215338
- Lead Sponsor
- Stanford University
- Brief Summary
This is a research study on human exercise that will investigate the immune system response post-exercise and how it relates to Delayed Onset Muscle Soreness (DOMS), and possible causes for DOMS.
Blood draws (10mL) will be obtained at 5 timepoints: Baseline before intervention, day of exercise immediately following exercise, and post-exercise days 1, 2 and 4.
Point of care lactate levels obtained before and after exercise.
Subjective pain scores recorded daily starting immediately after after exercise.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 22
- Ability to perform two arm bicep curl of at least 35 lb as 1 repetition maximum
- Autoimmune disease
- Steroid use
- On current immune-modifying treatment
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Mean change from baseline in phosphorylation markers in the JAK/STAT and TLR-pathway in immune cell populations From enrollment to 5 days after the end of treatment Collected at baseline from whole blood prior to exercise, day of exercise, post-exercise day 1, post-exercise day 2, post-exercise day 4
- Secondary Outcome Measures
Name Time Method Change from pre-exercise baseline in point of care lactate levels 1 day Two point of care lactate draws before and after exercise obtained in mmol/L
Change in Pain Scores from baseline From day of intervention daily for 5 days. Daily subjective pain scores recorded according to the Borg Perceived Pain Scale from 0 (no pain) to 11 (maximum pain)
Trial Locations
- Locations (1)
Stanford University
🇺🇸Stanford, California, United States
Stanford University🇺🇸Stanford, California, United States