Understanding and Mitigating Delayed Onset Muscle Soreness (DOMS)
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Stanford University
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Mean change from baseline in phosphorylation markers in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and Toll-like Receptor (TLR)-pathway in immune cell populations
Overview
Brief Summary
This is a research study on human exercise that will investigate the immune system response post-exercise and how it relates to Delayed Onset Muscle Soreness (DOMS), and possible causes for DOMS.
Blood draws (10mL) will be obtained at 5 timepoints: Baseline before intervention, day of exercise immediately following exercise, and post-exercise days 1, 2 and 4.
Point of care lactate levels obtained before and after exercise.
Subjective pain scores recorded daily starting immediately after after exercise.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •\- Ability to perform two arm bicep curl of at least 35 lb as 1 repetition maximum
Exclusion Criteria
- •Autoimmune disease
- •Steroid use
- •On current immune-modifying treatment
Outcomes
Primary Outcomes
Mean change from baseline in phosphorylation markers in the Janus kinase/signal transducer and activator of transcription (JAK/STAT) and Toll-like Receptor (TLR)-pathway in immune cell populations
Time Frame: From enrollment to 5 days after the end of treatment
Collected at baseline from whole blood prior to exercise, day of exercise, post-exercise day 1, post-exercise day 2, post-exercise day 4
Secondary Outcomes
- Change from pre-exercise baseline in point of care lactate levels(1 day)
- Change in Pain Scores from baseline(From day of intervention daily for 5 days.)
Investigators
H Craig Heller
Professor
Stanford University