Transversus Abdominus Plane Block

Not Applicable

Completed

• Conditions: Nephrectomy
• Interventions: Procedure: TAP block placement with placebo; Procedure: Placement of block with ropivacaine

• Registration Number: NCT01054469
• Lead Sponsor: Mayo Clinic

Brief Summary

Transversus Abdominus Plane (TAP) block may reduce need for postoperative pain medications in patients undergoing laparoscopic hand assisted nephrectomy. Our hypothesis is that the TAP block will result in a significant reduction in pain scores and morphine requirements in the active group.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-01-20
• Study First Submitted QC: 2010-01-20
• Study First Posted: 2010-01-22
• Study Start: 2010-03
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2012-06
• Last Update Submitted: 2012-06-20
• Last Update Posted: 2012-06-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Patients who are ≥ 18 and ≤ 80 years of age.
• Patients scheduled to undergo hand assisted laparoscopic removal of a single kidney for either tumor or living donor transplantation.

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Exclusion Criteria

• Patients scheduled to undergo an open procedure for nephrectomy
• Patients who are converted from hand assisted laparoscopic surgery to open surgery due to intraoperative complications.
• Bilateral nephrectomy
• Pregnant or lactating patients
• Patients unable or unwilling to provide informed consent
• Patients unable to comprehend the use of a visual analog scale
• Patients desiring preemptive antiemetics
• Opioid tolerance
• Allergy to amide local anesthetics or any of the study drugs (morphine).
• Contraindication to regional nerve block (bleeding disorder, infection at site of block)
• Patients with history of dementia

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TAP block with placebo	TAP block placement with placebo	-
TAP block with ropivacaine	Placement of block with ropivacaine	-

Primary Outcome Measures

Name	Time	Method
Determine if TAP block is a viable alternative to PCA narcotics for the control of pain after hand-assisted, laparoscopic nephrectomy.	24 hours postoperatively

Secondary Outcome Measures

Name	Time	Method
TAP block with ropivacaine will lead to equivalent or better results with regard to the following outcomes:pain scores, nausea, vomiting, sedation, request for PCA, discontinuation of Foley catheter, discharge from the hospital	24 hours postoperatively

Trial Locations

Locations (1)

Mayo Clinic; 🇺🇸 Jacksonville, Florida, United States