: Comparison of the action of of Dexmedetomidine and Magnesium Sulphate on Blood pressure and heart rate during laparoscopic surgeries.
- Conditions
- Calculus of gallbladder with othercholecystitis, (2) ICD-10 Condition: K811||Chronic cholecystitis, (3) ICD-10 Condition: N979||Female infertility, unspecified, (4) ICD-10 Condition: C569||Malignant neoplasm of unspecifiedovary, (5) ICD-10 Condition: O||Medical and Surgical, (6) ICD-10 Condition: N139||Obstructive and reflux uropathy, unspecified, (7) ICD-10 Condition: K36||Other appendicitis, (8) ICD-10 Condition: N950||Postmenopausal bleeding,
- Registration Number
- CTRI/2020/04/024931
- Lead Sponsor
- StJohns Medical college
- Brief Summary
Dexmedetomidine is an imidazole derivative and is highly selective alpha -2- adrenergic agonist . Alpha -2- agonist act on vascular pre-junctional terminals leading to decreased systemic noradrenaline release causing a decrease in blood pressure. it is known to attenuate the hypertensive response associated with intubation and pneumoperitoneum. Administered as a bolus dose 0.5-1 mcg/kg intravenously over 10-15 minutes. as infusion 0.1-1.5 mcg.kg/minute. it undergoes extensive biotransformation in liver and excreted through urine. there is no absolute contra indication to its use. side effects include hypotension, bradycardia, dry-mouty, hyperbilirubinimia, increased alanine transaminase and aspartate transferase.
Magnesium sulphate is a physiological and pharmacological blocker of N-methyl -D-aspartate receptors in neuronal tissue. Directly blocks the release of catecholamines from adrenal gland and adrenergic nerve terminals and indirectly by negative feed mechanism. it lso acts on blood vessels leading to vasodilation and decrease vasopressin stimulated vasoconstriction.parental magnesium sulphate has been used for many years as anti arrhythmic agents , for prophylaxis against seizure in pre-eclampsia patients.in the last decades its importance in anesthetic practice has been highlighted. side effects are nausea, vomiting, hypotension, head ache, lethargy. it can also potentiate neuromuscular blocking agents thus delaying the recovery.
both these drugs can attenuate the hemodynamic stress response to laryngoscopy, intubation and pneumoperitoneum in patients undergoing laparoscopic surgeries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Not Yet Recruiting
- Sex
- All
- Target Recruitment
- 84
Patients of either sex undergoing elective laparoscopic surgeries,ASA I and II,Age between 20 -59 years and Patients with Mallampatti grade I or II.
- •Any known allergy to the study drug •Pregnant women •BMI >35 kg/cm2 •Patients with pre-existing neuromuscular disease.
- •Patients with anticipated difficult airway.
- •More than one intubation attempt •Baseline heart rate< 60/ minute •Patients on beta- blockers and calcium channel blockers.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effects of intravenous Dexmedetomidine and Magnesium sulphate on hemodynamic changes occurring during laryngoscopy, intubation and during pneumoperitoneum in laparoscopic surgeries. 15 minutes prior to induction, at the time of induction, laryngoscopy ,1,3,5,10 minutes after intubation, at the time of pneumoperitoneum , 1,5,10, 30 minutes after pneumoperitoneum
- Secondary Outcome Measures
Name Time Method To assess any associated side effects like hypotension, bradycardia, dry mouth, nausea vomiting and allergic reactions. 30 minutes
Trial Locations
- Locations (1)
second floor operation theatre, preoperative room. room no 1,2,4.m
🇮🇳Bangalore, KARNATAKA, India
second floor operation theatre, preoperative room. room no 1,2,4.m🇮🇳Bangalore, KARNATAKA, IndiaNeethu P AntonyPrincipal investigator8884636709annchristychf@gmail.com