Efficacy Testing of Collagen and Zhuyin Drinks
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- The change of skin wrinkles
研究概览
简要总结
To assess collagen and zhuyin drink on skin & body condition improvement
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
Single
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adults aged above 20 years old
排除标准
- •Subject who is not willing to participate in this study.
- •Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history).
- •Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
- •Female who is pregnant or nursing or planning to become pregnant during the course of the study.
- •Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks.
- •Vegetarian
- •Subjects who have large spots (area >3 square centimeter) or abnormal acne.
结局指标
主要结局
The change of skin wrinkles
时间窗: Change from Baseline skin wrinkles at 4 weeks
VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units
The change of skin moisture
时间窗: Change from Baseline skin moisture at 4 weeks
Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
The change of skin collagen density
时间窗: Change from Baseline skin collagen density at 4 weeks
DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units:Intensity score
The change of skin brightness
时间窗: Change from Baseline skin brightness at 4 weeks
Glossymeter GL 200 was utilized to measure skin brightness. Units: arbitrary units
The change of interleukin-6
时间窗: Change from Baseline skin brightness at 4 weeks
Venous blood was sampled to measure concentrations of interleukin-6.
The change of Matrix metalloproteinase-1
时间窗: Change from Baseline skin brightness at 4 weeks
Venous blood was sampled to measure concentrations of Matrix metalloproteinase-1 .
The change of metallopeptidase inhibitor 1
时间窗: Change from Baseline skin brightness at 4 weeks
Venous blood was sampled to measure concentrations of metallopeptidase inhibitor 1.
The change of TEWL
时间窗: Change from Baseline TEWL at 4 weeks
Tewameter® TM 300 was utilized to measure TEWL. Units: g/h/m2
The change of interleukin-8
时间窗: Change from Baseline skin brightness at 4 weeks
Venous blood was sampled to measure concentrations of interleukin-8.
The change of Tumor necrosis factor
时间窗: Change from Baseline skin brightness at 4 weeks
Venous blood was sampled to measure concentrations of Tumor necrosis factor.
次要结局
- The change of skin pores(Change from Baseline skin pores at 4 weeks)
- The change of skin texture(Change from Baseline skin texture at 4 weeks)
- The change of skin spots(Change from Baseline skin spots at 4 weeks)
- The change of red areas(Change from Baseline red areas at 4 weeks)