Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink

Not Applicable

Completed

• Conditions: Skin Condition

• Registration Number: NCT05376657
• Lead Sponsor: TCI Co., Ltd.

Brief Summary

To assess cherry collagen drink on skin condition improvement

Detailed Description

Not available

Study Timeline

• Study Start: 2022-04-01
• Study First Submitted: 2022-05-12
• Study First Submitted QC: 2022-05-12
• Study First Posted: 2022-05-17
• Primary Completion: 2022-07-20
• Status Verified: 2022-09
• Study Completion: 2022-09-03
• Last Update Submitted: 2022-09-28
• Last Update Posted: 2022-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Healthy adults aged above 20 years old

Exclusion Criteria

• Subject who is not willing to participate in this study.
• Patients with diseases of the skin, liver, kidney.
• Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
• Female who is pregnant or nursing or planning to become pregnant during the course of the study.
• Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
• Constant drug use
• Students who are currently taking courses taught by the principal investigator of this trial.
• Body weight < 50 kg.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
The change of skin wrinkles	Change from Baseline skin wrinkles at 8 weeks	VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units
The change of skin texture	Change from Baseline skin texture at 8 weeks	VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
The change of skin collagen density	Change from Baseline skin collagen density at 8 weeks	DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units
The change of skin elasticity	Change from Baseline skin elasticity at 8 weeks	Soft Plus was utilized to measure skin elasticity. Units: arbitrary units

Secondary Outcome Measures

Name	Time	Method
The change of skin melanin index	Change from Baseline skin melanin index at 8 weeks	Soft Plus was utilized to measure skin melanin index. Units: arbitrary units
The change of skin moisture	Change from Baseline skin moisture at 8 weeks	Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
The change of skin spots	Change from Baseline skin spots at 8 weeks	VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
The change of skin brown spots	Change from Baseline skin brown spots at 8 weeks	VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units
The change of SOD-RBC of blood	Change from Baseline SOD-RBC at 8 weeks	Venous blood was sampled to measure SOD-RBC
The change of desmosine of blood	Change from Baseline desmosine at 8 weeks	Venous blood was sampled to measure concentrations of desmosine
The change of TNF-alpha of blood	Change from Baseline TNF-alpha at 8 weeks	Venous blood was sampled to measure concentrations of TNF-alpha
The change of transepidermal water loss (TEWL)	Change from Baseline TEWL at 8 weeks	Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²
The change of skin UV spots	Change from Baseline skin UV spots at 8 weeks	VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units
The change of t-GSH of blood	Change from Baseline t-GSH at 8 weeks	Venous blood was sampled to measure t-GSH
The change of GST-RBC of blood	Change from Baseline GST-RBC at 8 weeks	Venous blood was sampled to measure GST-RBC
The change of skin L* value	Change from Baseline L* value at 8 weeks	Chroma Meter MM500 was utilized to measure skin L\* value. Units: arbitrary units, 0-100
The change of blood total antioxidant capacity (TAC)	Change from Baseline TAC at 8 weeks	Venous blood was sampled to measure concentrations of TAC

Trial Locations

Locations (1)

Chia Nan University of Pharmacy & Science; 🇨🇳 Tainan City, Taiwan