TRUE-GRIT: Reducing cognitive impairment in glioma with repetitive transcranial magnetic stimulation and cognitive strategy training
- Conditions
- Brain tumorGlioma1002921110009841
- Registration Number
- NL-OMON53811
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 16
- >= 18 years of age
- Histological diagnosis of diffuse glioma (WHO grade 2,3, or 4)
- Subjective cognitive impairment, defined as CFQ-score >= 44
- Stable disease, i.e. no oncological treatment for <= 2 months prior to
inclusion; no radiological progression on the most recent MRI, not older than 6
months, and no clinical progression at inclusion
- Stable dosage (for at least 8 weeks) of anti-epileptic medication
- Current pregnancy or have given birth less than three months ago
- Current other treatment for cognitive complaints
- Karnofsky performance score <70
- A diffuse glioma located in the parietal cortex
- TMS exclusion: implanted medical devices (e.g. pacemaker, deep brain
stimulator, cochlear implants, medical infusion device, etc.); metal in the
body; dose change in antiepileptic drugs in the last 8 weeks; use of
pro-convulsive drugs; substance misuse or withdrawal; sleep deprivation
- MRI exclusion: extreme claustrophobia or metallic objects in or on the body
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method