Symptom-guided treatment influences brain plasticity - Neurofeedback-based training in patients with psychomotoric affective symptoms

Phase 1

Conditions: F32
F33
F31.3
F34
F20
F21
F22
F23
F24
F25

Registration Number: DRKS00014181

Lead Sponsor: niversitätsklinikum der RWTH Aachen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 60

Inclusion Criteria

Inclusion criteria for all participants:
- Age: 18 - 75 years,
- good knowledge of German.

Exclusion Criteria

Exclusion criteria for all participants:
- pregnancy or nursing period,
- contraindications to MR examinations, such as magnetic metal implants, large-scale tattoos or claustrophobia,
- Participants or patients that are not able to consent to the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The effect of neurofeedback training on apathy (lack of motivation) in patients diagnosed with depression will be assessed using the self-reported Apathy Evaluation Scale (AES) questionnaire. The participants will fill out the AES on the first day of enrollment. Following this day, on two other days a neurofeedback training will be performed using fMRI. The two measurement days in the cross-over design will be separated by a week. After the final day of training, we will issue another AES questionnaire to the participant. Following this, there will be a follow up day, approximately four weeks after the second measurement. On the follow up day, we will again issue the AES.<br>We will assess the effect our neurofeedback training paradigm had on the brain activity of the supplementary motor area (SMA) measured by fMRI. And how this change in SMA activity influences apathy in depressive patients.

Secondary Outcome Measures

Name	Time	Method
The effect of neurofeedback training on impulsivity in patients diagnosed with depression will be assessed using reaction times as measured by a Go-NoGo task. After the first day of enrollment, neurofeedback training will be performed using fMRI, on two more days. The two measurement days will be separated by a week. On each day there will be three neurofeedback training sessions during the measurement. Reaction times will be measured before the first session, then in between the next two sessions and also after the last session. The same will be repeated on the second measurement day.<br>It will be assessed the effect of our neurofeedback training paradigm on the brain activity of the supplementary motor area (SMA), measured by fMRI. And how this change in SMA activity influences impulsivity in depressive patients.