Determination of the bioavailability of folates with 15 N labelled folates in yeast
Not Applicable
- Conditions
- Healthy volunteers
- Registration Number
- DRKS00022344
- Lead Sponsor
- ehrstuhl für Analytische Lebensmittelchemie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 6
Inclusion Criteria
healthy female and male volunteers, between 18 and 30 years old, Caucasians, BMI lower 30kg/m2, non-smoker, informed consent
Exclusion Criteria
current participation in an intervention study; smoker; Alcohol addiction; lack of Vitamin B12/ hemoglobin and high level of homocysteine; chronic diseases; known allergy or intolerance against tested food; pregnant and lactating women; blood donation in the last 3 months; regular medication;
During the study: acute illness; intake of antibiotics, Breach of the study conditions; incalculable occurrences
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Determination of the plasma folate level in blood after the consumption of 15N-labelled folate, the folate supplement and the folate free food; generating a plasma folate curve out of 20 measuring points over a period of 24 h on each of the three study days
- Secondary Outcome Measures
Name Time Method Absorption of folates with drawing a conclusion for the pteroylpolyglutamate bioavailability; Difference between the test subjects; Effect of the methylenetetrahydrofolate reductase (MTHFR) genotype