To study the role of placental vitamin D receptor function alteration in growth restricted foetuses
Phase 4
- Conditions
- Health Condition 1: O098- Supervision of other high risk pregnancies
- Registration Number
- CTRI/2021/03/032210
- Lead Sponsor
- niversity of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
All pregnant women more than 28 weeks of gestation with USG diagnosed FGR
Spontaneous conception
Singleton pregnancy
Exclusion Criteria
A. Based oh history and examination
Hypertensive disorder of pregnancy, diabetes , chronic hypertension, renal disease , jaundice, epilepsy, multifetal pregnancy , prolonged PROM , SMOKING,ALCOHOL,DRUG abuse, placental abruption
B. If any of these investigations are abnormal:
OGTT , VDRL, TORCH IgM , Liver function test , Kidney function test, APLA, Fetal anomaly on USG
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Quantification of placental Vitamin D Receptor target gene expression in Idiopathic Fetal Growth Restriction affected pregnancies and low risk healthy pregnanciesTimepoint: 3 months post pooled sample collection
- Secondary Outcome Measures
Name Time Method 1. To correlate maternal vitamin D levels with placental Vitamin D receptor (VDR) target gene expression. <br/ ><br>2.To correlate maternal vitamin D levels with the severity of Fetal Growth Restriction <br/ ><br>3.To compare placental histopatholological features in Idiopathic Fetal Growth Restriction affected pregnancies with that of low risk pregnanciesTimepoint: July2021