Myocardial Performance at Rest and During Exercise in Heart Failure With Preserved Ejection Fraction: Speckle Tracking Echocardiography - One Piece of the Puzzle.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Mayo Clinic
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- Change in mean cardiac reserve as measured by strain rate
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
This study is being done to study how well the heart contracts and relaxes during exercise. In addition to traditional measures of heart function, we will use a new computer program that may improve understanding of why people feel shortness of breath or fatigue.
Detailed Description
Heart failure with preserved ejection fraction is not well understood, although account for nearly half of all heart failure cases. This study aims to collect data about systolic (contracting portion of a heart beat) and diastolic (relaxing portion of a heart beat) dysfunction at rest and during exercise. Participants with normal cardiac function will serve as a control group and compared to participants who are at risk of heart failure.
Investigators
Hector R. Villarraga, M.D.
PI
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •18 years of age or older,
- •able to exercise on a bicycle
Exclusion Criteria
- •heart arrhythmias,
- •severe chronic obstructive pulmonary disease,
- •congenital heart abnormalities,
- •infiltrative or hypertrophic cardiomyopathy.
Outcomes
Primary Outcomes
Change in mean cardiac reserve as measured by strain rate
Time Frame: Baseline, 12 weeks
Myocardial deformation imaging (e.g. strain, strain rate, torsion) requires clear 2-dimensional echocardiography images that will be obtain at rest and during mild and moderate intensity exercise. Images will be captured during 6-10 minute bouts of exercise on a tilting exercise table. Comparisons will be made on resting and exercise values between groups. Our hypothesis is that strain rate will not increase in patients at risk of heart failure demonstrating lack of cardiovascular reserve.
Secondary Outcomes
- Change in mean cardiac stroke volume(Baseline, 12 weeks)