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Clinical Trials/ChiCTR2000038234
ChiCTR2000038234Not yet recruitingUnknown

非甾体抗炎药在儿童 Gitelman 综合征中的临床应用及机制初探

首都儿科研究所所级课题1 site in 1 country30 target enrollmentStarted: October 10, 2020Last updated:
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Conditions
Interventions

Trial Snapshot

Phase
Unknown
Status
Not yet recruiting
Sponsor
Enrollment
30
Locations
1
Primary Endpoint
血钾
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

  1. 总结本院 Gitelman 综合征患儿的临床特点、诊治情况及预后分析；
  2. 小样本临床研究炎症非甾体抗炎药在 Gitelman 综合征患儿中是否具有普遍的治疗价值；
  3. 探讨环氧合酶抑制剂通过改善线粒体能量代谢等途径改善 GS 患儿小管功能的相关机制。

Study Design

Study Type
Observational

Eligibility Criteria

Ages
2 to 18 (—)
Sex
Male

Inclusion Criteria

  • •根据病史，除外饮食钾摄入不足、消化道失钾或利尿剂继发的低钾，除外钾分布异常；
  • •存在肾性失钾：即血钾小于 3.0 mmol/L 时，24 h 尿钾大于 20 mmol；
  • •或血钾小于 3.5 mmol/L 时，24 h 尿钾大于 25 mmol；

Exclusion Criteria

  • Not provided

Arms & Interventions

对照组

GS 组

吲哚美辛

Intervention: 吲哚美辛

Outcomes

Primary Outcomes

血钾

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
首都儿科研究所所级课题

Study Sites (1)

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