Comparison of Effects of Pitavastatin and Rosuvastatin on Patients With Chronic Heart Failure
Not Applicable
- Conditions
- heart failure
- Registration Number
- JPRN-UMIN000007695
- Lead Sponsor
- Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
Not provided
Exclusion Criteria
receiving treatment with a statin; taking a coenzyme Q10 (CoQ10) prior to the randomization and history of cardiac events. The ethics committee at Chiba University Graduate School of Medicine approved the OPAL protocol, which adhered according to the principles of the Helsinki Declaration
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method serum LDL-cholesterol, total CoQ10 and the following biomarkers; markers of inflammation (high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha ) and pentraxin 3 (PTX3)), marker of the severity of heart failure (N-terminal pro-brain natriuretic peptide (NT-proBNP), tenascin C, and high-sensitivity cardiac troponin T (hs-TnT)), a marker of oxidative stress (urinary 8-isoprostane) and a marker of chronic kidney disease (urinary albumin to creatinine ratio (UACR)) at 12 weeks
- Secondary Outcome Measures
Name Time Method