Clinical efficacy of Ding's manipulation in the treatment of knee osteoarthritis and its mechanism based on NF- kappa B signaling pathway
- Conditions
- Knee osteoarthritis
- Registration Number
- ITMCTR1900002314
- Lead Sponsor
- Shanghai University of Chinese Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
1. Repeated knee joint pain in the past month;
2. X-ray films (standing position or load-bearing position) showed narrowing of joint space, subcartilage osteosclerosis and / or cystic degeneration, and formation of osteophyte at the edge of the joint;
3. Aged = 50 years old;
4. Morning stiffness time = 30 min;
5. There is bone friction sound (feeling) during the activity.
1. There is skin damage around the knee joint;
2. Patients with history of knee surgery and severe trauma;
3. Patients with secondary OA, complicated with rheumatoid arthritis, gouty arthritis, infectious arthritis and other joint diseases;
4. Patients with diabetes, systemic infection, severe abnormal liver and kidney function, malignant tumor and other diseases;
5. Patients received NSAIDs, intra-articular injection and other related treatment in the past 3 months;
6. Those who are allergic to the drugs in this study;
7. Pregnant or lactating women;
8. Mental disorder or cognitive dysfunction;
9. Those who did not accept or could not adhere to the treatment plan of this study.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method VAS score;Womac score;
- Secondary Outcome Measures
Name Time Method