Effect of pump prime on bicarbonate, unmeasured ions, and acid-base balance during and after cardiopulmonary bypass

Phase 4

Completed

• Conditions: Acid-base disorders; Other -

• Registration Number: ACTRN12607000403437
• Lead Sponsor: Associate Professor David StoryAustin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-08-06
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Adults undergoing elective primary coronary artery bypass surgery.

Exclusion Criteria

Patient declines, age less than 18 years, age greater than 75 years, creatinine concentration greater than 150 micromoles/L, diabetes mellitus, anaemia (hemoglobin level <100g/L), pre-existing acid-base abnormalities, and extremes in weight (body weight <50kg or >100kg.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The base-excess will be measured in arterial blood sampled before bypass and then 2, 5, 10, 15 and 30 minutes after initiating bypass; and then 5 minutes after ceasing bypass and on arrival in Intensive Care. The difference between the grand means of base-excess will be compared between the Ringer's Injection and Hartmann's groups.[]

Secondary Outcome Measures

Name	Time	Method
Plasma electrolyte levels will be measured in arterial blood sampled before bypass and then 2, 5, 10, 15 and 30 minutes after initiating bypass; and then 5 minutes after ceasing bypass and on arrival in Intensive Care. The difference between the grand means of the electrolytes will be compared between the Ringer's Injection and Hartmann's groups.[]