Skeletal Muscle Energetics and Fatiguability in Older Individuals
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Maximal mitochondrial oxidative capacity (VmaxPCr)
研究概览
简要总结
The investigators are studying whether metabolic abnormalities in calf (leg) muscle in older people with and others without HIV are associated with decreased abilities to exercise.
详细描述
This research is being done to better understand why some older people living with HIV experience more fatigue and difficulty exercising than older people without HIV. This is important because fatigue and problems exercising are predictors of disability and hospitalization in older individuals. We will use non-invasive magnetic resonance imaging (MRI) and spectroscopy (MRS) of the leg muscle to measure muscle metabolites and fat content, as well as blood samples measures levels of inflammation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 60 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants who are >= 60 years of age
- •HIV serostatus positive participants on stable antiretroviral therapy (ART) (no regimen change in last month) with undetectable HIV viral load (<100 copies).
- •HIV serostatus negative participants
排除标准
- •Unable to understand the risks, benefits, and alternatives of participation and give meaningful consent
- •Contraindications to MRI
- •Significant cardiovascular, pulmonary or musculoskeletal or orthopedic disease that significantly limits exercise capacity
- •Significant lower extremity peripheral vascular disease.
- •Weight greater than 350 lbs
- •Cognitive or speech impairments that would limit completion of questionnaires or fatigue reporting.
研究组 & 干预措施
HIV
Participants (ages 60 and above) with HIV
Control
Participants (ages 60 and above) without HIV
结局指标
主要结局
Maximal mitochondrial oxidative capacity (VmaxPCr)
时间窗: Baseline
Maximal oxidative capacity of leg muscle measured by 31P Magnetic Resonance Spectroscopy (MRS)
Six minute walk distance
时间窗: Baseline
Rate of PCr decline during plantar flexion exercise
时间窗: Baseline
次要结局
- Skeletal muscle fat content(Baseline)
- Frailty status (as measured by the Fried Frailty Index)(Baseline)
- Gait speed(Baseline)