Preeclampsia and Defective Placentation in Oocyte Donation: Importance of HLA-C and KIR
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 2,325
- 主要终点
- Preeclampsia development.
研究概览
简要总结
The IMMUN-OR study aims to study HLA-C/KIR combinations when looking at the risk of development of preeclampsia (PE) in pregnancies after oocyte donation. With the use of oocyte donation currently on the rise, the importance of identifying risk factors for the higher frequency of PE development is clear. Certain HLA-C/KIR combinations have already been linked to higher risk of obstetric complications. This study will look at these combinations within the specific situation of oocyte donation. This will further investigate the importance of the immunological interface when looking at PE. Participants will be chosen from a database of all the live births after oocyte donation at our center. The research team will contact the mother, child and donor. If all three agree to participate, they will be invited to our center, where the research team will take a cheek swab. This swab will then be used to isolate a DNA sample. With these samples, we can determine the HLA-C/KIR combination for each threesome. When all samples have been collected, two groups are made based off their health outcome: one group that did develop PE during their pregnancy, and one group that did not develop PE. The different HLA-C/KIR combinations will be compared, and the research team will look to discover if one combination is linked to a higher occurrence of PE development.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Every live birth delivery post oocyte donation (mother, child, donor).
排除标准
- •Unknown HLA-C/KIR typing of acceptor, donor or offspring (resumlts of all 3 parties must be present to participate.
结局指标
主要结局
Preeclampsia development.
时间窗: From 20 weeks gestation until 6 weeks postpartum.
The development of PE throughout the pregnancy conceived through oocyte donation.
次要结局
- Development of early onset PE versus late onset PE.(From 20 weeks gestation until 6 weeks postpartum in pregnancies conceived through oocyte donation.)
- Preterm PE versus Term PE or PP PE(From 20 weeks gestation until 6 weeks postpartum in pregnancies conceived through oocyte donation.)
- Incidence of eclampsia, placental abruption, HELLP syndrome(From conception until 6 weeks postpartum in pregnancies conceived through oocyte donation.)
- Obstetrical complications(From conceptions until birth in pregnancies conceived through oocyte donation.)
- Delivery characteristics(From conception until birth in pregnancies conceived through oocyte donation.)
研究者
Neelke De Munck
Head of the ART lab
Universitair Ziekenhuis Brussel