Brain Metabolism in Women With Polycystic Ovary Syndrome: a PET/MRI Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 主要终点
- Insulin Resistance (HOMA2-IR)
研究概览
简要总结
The purpose of this study is to investigate whether higher insulin resistance in young women with Polycystic ovary syndrome (PCOS) is associated with reduced cerebral metabolic rate of glucose (CMRglu). Brain volumes using magnetic resonance imaging (MRI) and quantitative cerebral glucose uptake using dynamic positron emission tomography (PET) were obtained.
详细描述
MRI and FDG PET scan for each participant were obtained within an average time frame of 3 weeks. Isulin resistance were assessed with the updated homeostasis model assessment (HOMA2-IR).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of PCOS
- •Age ≤ 35 y
排除标准
- •Taking medications for diabetes or insulin-sensitizing drugs
- •Drug addictions
- •Psychiatric illness
- •Overt evidence of heart, liver or renal disease
结局指标
主要结局
Insulin Resistance (HOMA2-IR)
时间窗: Single point in time (day 1 during the FDG PET)
The homeostasis model assessment computational method was used to estimate insulin resistance (HOMA2-IR) from fasting plasma glucose and insulin. The HOMA2-IR is the reciprocal of insulin sensitivity (%S), as a percentage of a normal reference population (normal young adult). A higher score indicates a lower insulin sensitivity.
Global Brain Glucose PET Uptake
时间窗: Single point in time (day 1)
Global brain glucose uptake was quantified using FDG with dynamic positron emission tomography.
Brain MR Volumes
时间窗: Single point in time (day 2)
T1-weighted brain MR images were obtained on a 1.5 Tesla scanner. Regional volumes were determined using FreeSurfer Suite 5.0 software.
次要结局
未报告次要终点