Effect of Arterial Oxygen Partial Pressure on Mixed Venous Oxygen Saturation

Not Applicable

Completed

• Conditions: Anemia
• Interventions: Other: Change of the fraction of inspired oxygen

• Registration Number: NCT04144205
• Lead Sponsor: Seoul National University Hospital

Brief Summary

Mixed venous oxygen saturation is known to reflect oxygen delivery and, thus, is frequently monitored in patients undergoing cardiac surgery. Factors that affect mixed venous oxygen saturation include hemoglobin level, arterial oxygen saturation and arterial oxygen partial pressure. Among them, arterial oxygen partial pressure is known to have minimal effect on oxygen delivery compared to hemoglobin and arterial oxygen saturation. However, some argues that in certain clinical setting, such as anemia which is very common in cardiac surgery patients, the contribution of plasma (arterial oxygen partial pressure in this case) to oxygen delivery becomes more significant. Therefore, we planned to perform a pilot clinical trial to observe the change of oxygen delivery, which would be reflected in mixed venous oxygen saturation and cerebral regional oxygen saturation, according to hemoglobin level.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-10-28
• Study First Submitted QC: 2019-10-28
• Study First Posted: 2019-10-30
• Study Start: 2019-11-04
• Status Verified: 2020-02
• Primary Completion: 2020-02-11
• Study Completion: 2020-02-11
• Last Update Submitted: 2020-02-20
• Last Update Posted: 2020-02-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Patients that scheduled to undergo cardiac surgery using cardiopulmonary bypass.

Exclusion Criteria

• Emergent surgery
• Symptomatic carotid artery stenosis or carotid artery stenosis of ≥50%
• Preoperative oxygen therapy that is equivalent to the inspired oxygen fraction of 0.5.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Fraction of inspired oxygen setting change	Change of the fraction of inspired oxygen	-

Primary Outcome Measures

Name	Time	Method
Mixed venous oxygen saturation	From the beginning and the stabilization of cardiopulmonary bypass to 15 minutes thereafter.	Change of mixed venous oxygen saturation according to the fraction of inspired oxygen

Secondary Outcome Measures

Name	Time	Method
Cerebral regional oxygen saturation	From the beginning and the stabilization of cardiopulmonary bypass to 15 minutes thereafter.	Change of cerebral regional oxygen saturation according to the fraction of inspired oxygen

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of