Accuracy of the Pleth Variability Index to Predict Fluid Responsiveness in Liver Transplantation

Phase 4

Completed

• Conditions: Hemodynamic Instability

• Registration Number: NCT01792011
• Lead Sponsor: Inonu University

Brief Summary

The aim of this study is to compare the accuracy of PVI (pleth variability index)

Detailed Description

The aim of this study is to compare the accuracy of PVI (pleth variability index)with other hemodynamic variability that measured with PİCCO (SVV, PPV, CVP,CI)to predict the response of cardiac index to volume replacement in patients undergoing liver transplantation.

Study Timeline

• Study Start: 2012-10
• Status Verified: 2013-02
• Primary Completion: 2013-02
• Study Completion: 2013-02
• Study First Submitted: 2013-02-08
• Study First Submitted QC: 2013-02-13
• Last Update Submitted: 2013-02-13
• Study First Posted: 2013-02-15
• Last Update Posted: 2013-02-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Elective living donor liver transplantation,
• >18 years patients

Exclusion Criteria

Patients with:

• Arrhythmia
• Reduced left ventricular function (EF<40%)
• Hepatocellular carcinoma
• Pulmonary hypertension
• Fulminant liver failure
• valvular heart disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
To test the ability of PVI to detect changes in preload during orthotopic liver transplantation	During dissection and anhepatic phase (3 months)	PVI is a measure of the dynamic changes in perfusion index that occur during a complete respiratory cycle

Trial Locations

Locations (1)

Inonu University Faculty of Medicine Department of Anesthesiology and Reanimation; 🇹🇷 Malatya, Turkey