Trial Comparing hCG Triggering Versus GnRH Agonist Triggering in PCOS Patients
- Registration Number
- NCT01683513
- Lead Sponsor
- AZ Jan Palfijn Gent
- Brief Summary
In this study the investigators compare the traditional way of triggering with a new way in patients with Poly Cystic Ovary Syndrome (PCOS). This to reduce the risque of Ovary Hyper Stimulation Syndrome (OHSS) in In Vitro Fertilization/ IntraCytoplastic Sperm Injection (IVF/ ICSI) treatment. The investigators also compare the number of mature oocytes, embryo's and pregnancy rate.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 120
Inclusion Criteria
- ICSI patients below 38 years
- 1, 2 and 3e IVF cycle
- Body Mass Index (BMI) less than 32
- PCOS patients
Exclusion Criteria
- endocrinal diseases or problems
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description GnRH agonist + 1500E hCG GnRh agonist +1500E hCG ovulation induction with GnRH agonist and 1500E hCG one hour after egg retrieval
- Primary Outcome Measures
Name Time Method MII oocytes patients will be followed during the stimulation with an average of 10 days The number of mature oocytes retrieved after stimulation without creating OHSS
2 Pro Nuclei (2PN) fertilization 24h after ICSI laboratory follow up of the fertilized egg during the first 24h
- Secondary Outcome Measures
Name Time Method implantation rate 12 weeks The number of pregnancies obtained wich still is the most important issue for the patients
OHSS one month with oocyte retrieval in the middle patient follow up according to subjective complaints and objective measures
Trial Locations
- Locations (1)
AZ Jan Palfijn
🇧🇪Gent, Oost-vlaanderen, Belgium