Effect of platelet-rich plasma gel on intrauterine adhesions

Not Applicable

Completed

• Conditions: Intrauterine adhesion; Urological and Genital Diseases

• Registration Number: ISRCTN59253147
• Lead Sponsor: Sheng Jing Hospital

Brief Summary

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37552284/ (added 02/09/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-02
• Study Completion: 2021-05-31
• Last Update Posted: 9 September 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

1. Moderate to severe intrauterine adhesion (AFS score =5)
2. No previous history of hysteroscopic adhesiolysis
3. Written consent obtained
4. Agreement to have second-look hysteroscopy
5. All the participants should be =18 years and younger than 40 years old

Exclusion Criteria

1. Pregnancy or breastfeeding women
2. Minimal adhesion(AFS<5)
3. Previous history of hysteroscopic adhesiolysis
4. Highly allergic constitution or a history of severe allergic to thrombin
5. Systemic infection or severe local infection
6. Amenorrhea due to ovarian hypofunction or other causes
7. Severe cardiopulmonary disease, liver and kidney dysfunction and other severe underlying disease
8. Poor compliance (cannot finish the trial) or the investigator believes that the patient is not appropriate for treatment

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The severity and extent of intrauterine adhesions scored according to a classification system recommended by the American Fertility Society (AFS) (1988 version), measured 2 months after surgery

Secondary Outcome Measures

Name	Time	Method
Pregnancy rates measured using ultrasound after the operation until 1 year after the termination of the clinical trial