Integrating Pain-CBT Into an mHealth Analgesic Support Intervention for Patients With Chronic Pain From Advanced Cancers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pain
- Sponsor
- Dana-Farber Cancer Institute
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Overall intervention adherence rate (Cohort C)
- Status
- Recruiting
- Last Updated
- 11 months ago
Overview
Brief Summary
Smartphone Technology to Alleviate Malignant Pain (STAMP) + Cognitive Behavioral Therapy for Pain (STAMP+CBT) The purpose of the study is to develop and refine the mHealth pain-CBT app intervention and carry out a randomized pilot to test the novel mHealth (Mobile health technology) intervention, which harmonizes psychological and pharmacological support for advanced cancer pain.
The name of the study smartphone application involved in this study is:
-STAMP+CBT
Detailed Description
The purpose of the study is to make sure the app is usable and helpful for participants with cancer and to get feedback about participants experiences after using the app for four weeks. Outcomes related to pain, quality of life, and healthcare utilization will also be assessed. The cancer pain education packet and pain and medication monitoring survey are standard care. The app is intended to improve self-management of cancer-related pain. The study will begin with Cohort A, followed by Cohort B. These two cohorts are to refine the STAMP+CBT intervention. Then a randomized pilot will be performed, and participants will be randomized into one of two study groups for the pilot: Cohort C: STAMP+CBT versus Cohort D: Digital Cancer Pain Education Packet + Usual Care. Randomization means a participant is placed into a study group by chance. It is expected that about 60 people will take part in this research study. The National Institutes of Health, National Cancer Institute (NIH-NCI), is funding this research study.
Investigators
Desiree R. Azizoddin PsyD
Principle Investigator
Dana-Farber Cancer Institute
Eligibility Criteria
Inclusion Criteria
- •Age ≥ 22 years
- •Patient diagnosed with an active cancer diagnosis (locally advanced solid tumor malignancy, multiple myeloma, or other advanced hematologic malignancy), either undergoing active treatment or receiving treatment for an advanced cancer or are receiving supportive/palliative care
- •Chronic pain related to cancer or treatment (\> pain score of 4 on a 0-10 scale)
- •Has an active prescription for at least one opioid medication to treat their cancer pain (i.e. not for post-surgical pain)
- •Own/use a compatible smartphone (iPhone or Android)
Exclusion Criteria
- •Patients in survivorship: patients who have completed their treatment regimens, are not actively receiving treatment for an advanced cancer, or have a cancer that is in remission
- •Cognitive impairment that would interfere with study participation, as judged by treating clinician (e.g. delirium, dementia)
- •Inability to speak English (the intervention has not yet been translated to Spanish)
- •Currently in CBT treatment
- •Enrolled in hospice
- •Currently hospitalized
- •Use of transmucosal fentanyl, given safety concerns and ongoing risk mitigation program required to prescribe these (TIRF REMS)
- •Pain primarily related to a recent surgery (within the last 2 weeks)
- •Conditions that hinder smartphone use
- •The study will exclude adults who are unable to consent, individuals who are not yet adults (infants, children, teenagers), pregnant women, and prisoners.
Outcomes
Primary Outcomes
Overall intervention adherence rate (Cohort C)
Time Frame: Up to 4 weeks
\>70% of subjects complete any activity on the STAMP+CBT application at least 50% of days on study (4-week study period). The app will be considered feasible if this benchmark is achieved.
Overall intervention adherence rate (Cohort D)
Time Frame: Up to 4 weeks
Defined as completion of the 14- and 28-days surveys, which assesses completion of the pain and medication monitoring reports by participants in the control group.
Proportion of participants who rate app acceptability at least 4/5 on the Acceptability E-Scale (Cohort C)
Time Frame: Up to 6 weeks
Acceptability of the intervention is defined as \> 80% of the participants rate the application as satisfactory and useful with a mean 4 or higher score out of 5 on the Acceptability E-Scale (Tariman 2011). The Acceptability E-Scale a 7-item measure with answer ranging from 1 "Very Difficulty/Difficult to understand/Not at all/Very unacceptable/Very dissatisfied/Not useful/Very unlikely" to 5 "Very Easy/Easy to understand/Very much/ Very acceptable/Very satisfied/Very useful/Very likely" and with a total scores range of 7 to 35 with a higher score representing greater participant acceptability. Subjects will be assigned surveys at baseline, 4 weeks, and 6 weeks. Participants will rate the app on the following 5 domains: understandability, enjoyability, ease of use, time required to use the app, and overall satisfaction. Ratings lower than 4/5 will lead to refinements.
Proportion of participants who rate educational packet acceptability at least 4/5 on the Acceptability E-Scale (Cohort D)
Time Frame: Up to 6 weeks
Acceptability of the intervention is defined as \> 80% of the participants rate the application as satisfactory and useful with a mean 4 or higher score out of 5 on the Acceptability E-Scale (Tariman 2011). The Acceptability E-Scale a 7-item measure with answer ranging from 1 "Very Difficulty/Difficult to understand/Not at all/Very unacceptable/Very dissatisfied/Not useful/Very unlikely" to 5 "Very Easy/Easy to understand/Very much/ Very acceptable/Very satisfied/Very useful/Very likely" and with a total scores range of 7 to 35 with a higher score representing greater participant acceptability. Subjects will be assigned surveys at baseline, 4 weeks, and 6 weeks. Participants will rate the app on the following 5 domains: understandability, enjoyability, ease of use, time required to use the app, and overall satisfaction. Ratings lower than 4/5 will lead to refinements.
Secondary Outcomes
- Number of Enrolled Participants who Consented and Completed the Study (Cohort C)(18 months)
- Number of Enrolled Participants who Consented and Completed the Study (Cohort D)(18 months)
- Study Retention (Cohort C)(18 months)
- Study Retention (Cohort D)(18 months)
- Median assessment score on the system usability scale at 4 weeks (Cohort C)(Up to 6 weeks)
- Median assessment score on the system usability scale at 4 weeks (Cohort D)(Up to 6 weeks)
- Change in Brief Pain Inventory (BPI) Pain Interference Score from Baseline to 4 and 6 Weeks (Cohort C)(Up to 6 weeks)
- Change in BPI Pain Interference Score from Baseline to 4 and 6 Weeks (Cohort D)(Up to 6 weeks)
- Change in BPI Pain Intensity Score from Baseline to 4 and 6 Weeks (Cohort C)(Up to 6 weeks)
- Change in BPI Pain Intensity Score from Baseline to 4 and 6 Weeks (Cohort D)(Up to 6 weeks)