Effect of Endometrial Perfusion of Platelet Rich Plasma (PRP) on success of Frozen Embryo Transfer (FET)

The assisted reproductive technology (ART) method of frozen embryo transfer (FET) is now often used to produce healthy babies. Adjunctive medications to enhance endometrial receptivity are being investigated, nevertheless, because implantation failure continues to be a major obstacle. Endometrial perfusion and responsiveness may be modulated by platelet-rich plasma (PRP), which is abundant in growth factors and cytokines.  In order to assess the impact of PRP endometrial perfusion on the success of frozen embryo transfer, this abstract undertakes a meta-analysis of the literature. Research examining the effect of PRP on FET outcomes was included in the eligible papers, which also included prospective cohort studies and retrospective analyses.  When comparing the clinical pregnancy rates of women undergoing FET with endometrial perfusion of PRP to controls, a pooled analysis of data from specific studies shows a substantial improvement (p < 0.05). Moreover, a dose-response relationship is suggested by the positive association shown by meta-regression analysis between the concentration of platelets in PRP and pregnancy outcomes. Subgroup studies that take into account the patient’s demographics, the cause of their infertility, and the methods used to prepare PRP offer valuable information on possible causes of heterogeneity and variances in treatment outcomes. Notably, there is no discernible rise in adverse events recorded across studies, suggesting that PRP treatment has a positive safety profile.  Although the results indicate that PRP may be useful in improving endometrial receptivity and FET success, there are a number of limitations that should be taken into consideration when interpreting the results. These include limited sample sizes, heterogeneity in study designs, and variability in PRP preparation techniques. Larger sample sizes and more carefully planned RCTs are required in the future to confirm these results and clarify the best PRP delivery schedule for enhancing FET outcomes.  To sum up, endometrial perfusion of PRP exhibits potential as a viable adjuvant therapy to augment the effectiveness of frozen embryo transfer, providing fresh opportunities to improve patient outcomes and pregnancy rates in assisted reproductive environments.