Effect of Prior Administration of the drug Ibuprofen-Arginine on the success of Anesthetic Block for Root Canal Treatment of posterior lower teeth with Symptomatic Pulpitis
- Conditions
- Pulpitis
- Registration Number
- RBR-6z4jrs8
- Lead Sponsor
- Faculdade de Odontologia da Universidade Federal de Goiás
- Brief Summary
Introduction: This study evaluated the effect of premedication with ibuprofen and ibuprofen-arginine, and the influence of preoperative pain and anxiety on inferior alveolar nerve block (IANB) with 2.0% lidocaine in cases of symptomatic irreversible pulpitis (SIP). Methods: 150 patients diagnosed with SIP in the mandibular posterior teeth randomly received ibuprofen (600mg), ibuprofen-arginine (1,155mg), or placebo, 30 minutes before the IANB. The level of preoperative anxiety and pain intensity were assessed using the Modified Dental Anxiety Scale and the Heft-Parker visual scale. The IANB was considered efficient when reporting absence of or mild pain during treatment. The chi-square and z tests were used to evaluate categorical variables. Quantitative variables were evaluated by Analysis of Variance. Differences among the means of the groups were evaluated by Student's test. Variables with non-normal distribution were compared using the Kruskal-Wallis or Mann-Whitney tests. Results: The groups that received ibuprofen and ibuprofen-arginine had significantly higher rates of IANB efficiency, 62% and 78%, respectively, compared with placebo (34%); however, there was no significant difference between the ibuprofen and ibuprofen- arginine groups. Patients who had efficient block in the ibuprofen and ibuprofen-arginine groups had lower median anxiety than those with failed block, 8 versus 15, respectively, and lower mean preoperative pain (118.3). Conclusion: Preemptive ibuprofen-arginine medication increased the efficacy of the IANB; however, there was no significant difference with ibuprofen. The influence exerted by the level of preoperative anxiety and pain intensity should be considered.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Be in good health; Be in the age group over 18 years; Present a clinical diagnosis of symptomatic pulpitis in posterior lower teeth; Ability to understand the pain assessment scale
Under 18 years old; pregnant women; Patients who have a previous sensitivity, allergy or who cannot take ibuprofen for any other reason; Patients allergic to local anesthetics or sulfites; Patients who have an important history of health problems; Patients unable to give informed consent; Patients who have ingested analgesics or anti-inflammatory drugs in the last 8 hours prior to treatment
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Expected outcome 1: Increased efficacy of anesthetic blockade of the inferior alveolar nerve, verified upon previous administration of arginine ibuprofen for endodontic treatment in patients with symptomatic pulpitis.;Outcome found 1: In the present investigation, preemptive medication with ibuprofen-arginine provided a rate of 78.0% of efficient blockade of the inferior alveolar nerve and of 62.0% when conventional ibuprofen was used. Despite the results of the ibuprofen-arginine association showing higher values, there was no statistical difference between the two groups in terms of blockade efficiency.
- Secondary Outcome Measures
Name Time Method Secondary outcomes are not expected