Intraoperative Sedation and Postoperative Delirium

Completed

• Conditions: Orthopedics
• Interventions: Drug: Dexmedetomidine; Drug: Propofol

• Registration Number: NCT02573558
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

Delirium are common after orthopedic surgery in the elderly and are directly associated with loss of independence, reduction in the quality of life and increased mortality. The cause of postoperative delirium still remains unclear and may be multifactorial. The aim of this retrospective study is to examine prevalence of postoperative delirium according to the use of dexmedetomidine or propofol in elderly patients undergoing orthopedic surgery under regional anesthesia.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2015-10
• Study First Submitted: 2015-10-06
• Study First Submitted QC: 2015-10-07
• Study First Posted: 2015-10-12
• Primary Completion: 2016-01
• Study Completion: 2016-01
• Status Verified: 2016-04
• Last Update Submitted: 2016-04-05
• Last Update Posted: 2016-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 855

Inclusion Criteria

• Patients who underwent orthopedic surgery under regional anesthesia
• age of 65 years or greater

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Exclusion Criteria

• General anesthesia
• age < 65 years
• central nervous system disease, including dementia and Parkinson's disease
• Patients who were not received sedation with propofol or dexmedetomidine during the operation

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
DEX	Dexmedetomidine	patients who received dexmedetomidine during the operation
PPF	Propofol	patients who received propofol during the operation

Primary Outcome Measures

Name	Time	Method
delirium	within 7 day postoperatively

Secondary Outcome Measures

Name	Time	Method
Pulmonary thromboembolism	within 7 day postoperatively
Hospital stay	through study completion, an average of 7days
Wound infection	within 7 day postoperatively

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Gyeonggi, Korea, Republic of