Staphylococcus aureus Network Adaptive Platform trial (SNAP)
- Conditions
- Staphylococcus aureus bacteraemiaInfections and Infestations
- Registration Number
- ISRCTN17997749
- Lead Sponsor
- niversity College London
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Ongoing
- Sex
- All
- Target Recruitment
- 7000
1. Staphylococcus aureus complex grown from =1 blood culture
2. Admitted to participating hospital at anticipated time of eligibility assessment
3. Appropriate consent has been obtained for the patient’s participation in the trial
1. Time of anticipated platform entry is greater than 72 h post collection of the index blood culture
2. Polymicrobial bacteraemia, defined as more than one organism (at species level) in the index blood cultures, excluding those organisms judged to be contaminants by the treating clinicians
3. Patient currently being treated with a systemic antibacterial agent that cannot be ceased or substituted for interventions allocated within the platform (unless antibiotic is listed in Table 1, which specifies allowed antibiotics with limited absorption from the gastrointestinal tract or negligible antimicrobial activity against S. aureus)
4. Known previous participation in SNAP
5. Known positive blood culture for S. aureus (of the same silo: PSSA, MSSA or MRSA) between 72 h and 180 days prior to the time of eligibility assessment
6. Treating team deems enrolment in the study is not in the best interest of the patient
7. Treating clinician believes that death is imminent and inevitable
8. Patient is for end-of-life care and antibiotic treatment is considered not appropriate
9. Patient <18 years of age and paediatric recruitment not approved at recruiting site
10. Patient has died since the collection of the index blood culture
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause mortality at 90 days after platform entry determined through a search of hospital databases for a record of a participant’s death, or follow-up contact with the participant’s community healthcare provider, or follow-up contact with the patient or their nominated carer, or linkage with death registries.
- Secondary Outcome Measures
Name Time Method