Cysteine

Generic Name: Cysteine

Brand Names: Elcys, Freamine 6.9, Freamine III 10, Hepatamine 8, Nephramine, Nouress, Premasol, Primene, Procalamine 3, Trophamine 10 %

Drug Type: Small Molecule

Chemical Formula: C_₃H_₇NO_₂S

CAS Number: 52-90-4

Unique Ingredient Identifier: K848JZ4886

Background: A thiol-containing non-essential amino acid that is oxidized to form cystine.

Indication: For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen

Associated Therapies: Total parenteral nutrition therapy, Amino acid supplementation

Clinical Trials

NAC for Head Trauma-induced Anosmia

Phase 3

Terminated

Conditions: Anosmia
Head Trauma

Interventions: Drug: Placebo oral capsule
Drug: N Acetyl Cysteine

First Posted Date: 2018-09-21

Last Posted Date: 2021-02-04

Lead Sponsor: University of Miami

Target Recruit Count: 7

Registration Number: NCT03680911

Locations: 🇺🇸
University Of Miami, Otolaryngology Department, Miami, Florida, United States

N-Acetylcysteine in Biliary Atresia After Kasai Portoenterostomy

Phase 2

Completed

Conditions: Biliary Atresia

Interventions: Drug: N-Acetyl cysteine

First Posted Date: 2018-04-17

Last Posted Date: 2024-03-26

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 13

Registration Number: NCT03499249

Locations: 🇺🇸
Texas Children's Hospital and Baylor College of Medicine, Houston, Texas, United States

N-Acetyl Cysteine Protects Pulpal Stem Cells in Endodontic Revascularization

Early Phase 1

Conditions: Endodontic Disease

Interventions: Drug: N acetyl cysteine

First Posted Date: 2018-03-01

Last Posted Date: 2019-10-30

Lead Sponsor: University of California, Los Angeles

Target Recruit Count: 14

Registration Number: NCT03451435

Locations: 🇺🇸
University of California, Los Angeles Dept of Graduate Endodontics, Los Angeles, California, United States

Prevention of Acute Kidney Injury by N-Acetylcystein in Patients Undergone Cardiac Valve Replacement

Phase 4

Conditions: Surgery--Complications
Post-Op Complication
Cardiac Valve Disease
Acute Kidney Injury
Oxygen Radical Damage

Interventions: Drug: N Acetyl Cysteine
Drug: Placebos

First Posted Date: 2018-02-22

Last Posted Date: 2018-03-05

Lead Sponsor: University of Sao Paulo General Hospital

Target Recruit Count: 154

Registration Number: NCT03440268

Locations: 🇧🇷
José Jayme Galvão de Lima, São Paulo, Brazil

Nebulized N-Acetyl Cysteine for Bronchiolitis in Inpatient Hospital Use

Phase 4

Conditions: Bronchiolitis Acute

Interventions: Drug: N-Acetyl Cysteine

First Posted Date: 2017-12-06

Last Posted Date: 2019-09-26

Lead Sponsor: Carilion Clinic

Target Recruit Count: 106

Registration Number: NCT03364218

Locations: 🇺🇸
Carilion Clinic, Roanoke, Virginia, United States

Pilot Study: Postoperative Pain Reduction by Pre Emptive N-Acetylcysteine

Phase 4

Completed

Conditions: Postoperative Pain

Interventions: Drug: Acetyl cysteine
Drug: Placebos

First Posted Date: 2017-11-28

Last Posted Date: 2019-08-13

Lead Sponsor: Radboud University Medical Center

Target Recruit Count: 60

Registration Number: NCT03354572

Locations: 🇳🇱
Maxima Medical Centre, Eindhoven, Noord Brabant, Netherlands

N-Acetyl-cysteine in Early Acute Respiratory Distress Syndrome

Early Phase 1

Withdrawn

Conditions: Acute Respiratory Distress Syndrome

Interventions: Drug: N-acetyl cysteine

First Posted Date: 2017-11-17

Last Posted Date: 2024-10-31

Lead Sponsor: Prisma Health-Midlands

Registration Number: NCT03346681

Locations: 🇺🇸
Palmetto Health Richland, Columbia, South Carolina, United States

Influence of n-Acetylcysteine Maintenance on Alcohol Effects

Early Phase 1

Completed

Conditions: Alcohol Use Disorder

Interventions: Drug: Alcohol
Drug: Placebos
Drug: N-acetyl cysteine

First Posted Date: 2017-07-13

Last Posted Date: 2021-01-26

Lead Sponsor: William Stoops

Target Recruit Count: 14

Registration Number: NCT03216954

Locations: 🇺🇸
University of Kentucky, Lexington, Kentucky, United States

Marijuana Cue-Reactivity & Seeking Behavior in Regular Cannabis Users

Phase 1

Completed

Conditions: Marijuana Abuse

Interventions: Drug: N-acetyl cysteine

First Posted Date: 2017-05-16

Last Posted Date: 2024-04-23

Lead Sponsor: Wayne State University

Target Recruit Count: 21

Registration Number: NCT03154580

Locations: 🇺🇸
Tolan Park Medical Building, Detroit, Michigan, United States

N-ACetylcysteine to Reduce Infection and Mortality for Alcoholic Hepatitis

Phase 3

Recruiting

Conditions: Alcoholic Hepatitis
Infection

Interventions: Drug: N-acetyl cysteine (NAC)

First Posted Date: 2017-03-03

Last Posted Date: 2021-11-09

Lead Sponsor: Imperial College London

Target Recruit Count: 42

Registration Number: NCT03069300

Locations: 🇬🇧
St Mary's Hospital, Imperial College, London, United Kingdom

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