Quinidine

Generic Name: Quinidine

Brand Names: Nuedexta

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₄N_₂O_₂

CAS Number: 56-54-2

Unique Ingredient Identifier: ITX08688JL

Background: Quinidine is a D-isomer of quinine present in the bark of the Cinchona tree and similar plant species. This alkaloid was first described in 1848 and has a long history as an antiarrhythmic medication. Quinidine is considered the first antiarrhythmic drug (class Ia) and is moderately efficacious in the acute conversion of atrial fibrillation to normal sinus r...

Indication: Quinidine is indicated for the management and prophylactic therapy of atrial fibrillation/flutter, as well as the suppression of recurrent documented ventricular arrhythmias. It is also used in the treatment of Brugada syndrome, short QT syndrome and idiopathic ventricular fibrillation..

Associated Conditions: Atrial Fibrillation or Flutter, Malaria caused by Plasmodium falciparum, Pseudobulbar Affect (PBA), Ventricular Arrhythmia

Associated Therapies: -

Clinical Trials

A Drug-Drug Interaction Study of Orforglipron (LY3502970) with Quinidine in Healthy Participants

Phase 1

Not yet recruiting

Conditions: Healthy

Interventions: Drug: Orforglipron
Drug: Midazolam
Drug: Quinidine

First Posted Date: 2024-11-26

Last Posted Date: 2024-11-26

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 28

Registration Number: NCT06704763

Locations: 🇺🇸
ICON, Salt Lake City, Utah, United States

A Study to Assess the Effect of Voriconazole and Quinidine on the Pharmacokinetics of a Single Dose of Repotrectinib in Healthy Participants

Phase 1

Not yet recruiting

Conditions: Healthy Volunteers

Interventions: Drug: Repotrectinib
Drug: Voriconazole
Drug: Quinidine

First Posted Date: 2024-07-10

Last Posted Date: 2024-07-10

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 32

Registration Number: NCT06493409

Locations: 🇺🇸
Fortrea - Daytona Beach, Daytona Beach, Florida, United States

Drug-Drug Interaction Study Between EDP-235, Itraconazole, Carbamazepine and Quinidine in Healthy Subjects.

Phase 1

Completed

Conditions: COVID-19

Interventions: Drug: EDP-235
Drug: Carbamazepine
Drug: Itraconazole
Drug: Quinidine

First Posted Date: 2022-10-26

Last Posted Date: 2023-04-27

Lead Sponsor: Enanta Pharmaceuticals, Inc

Target Recruit Count: 36

Registration Number: NCT05594602

Locations: 🇺🇸
ICON, plc., Lenexa, Kansas, United States

Quinidine Versus Verapamil in Short-coupled Idiopathic Ventricular Fibrillation

Phase 2

Conditions: Short-coupled Idiopathic Ventricular Fibrillation

Interventions: Drug: Quinidine
Drug: Verapamil

First Posted Date: 2022-10-25

Last Posted Date: 2023-09-13

Lead Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Target Recruit Count: 24

Registration Number: NCT05593757

Locations: 🇳🇱
Academic Medical Center, Amsterdam, Noord-Holland, Netherlands

A Study of Imlunestrant (LY3484356) in Female Healthy Participants

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: Imlunestrant
Drug: Omeprazole
Drug: Repaglinide
Drug: Quinidine
Drug: Rosuvastatin
Drug: Dextromethorphan
Drug: Digoxin

First Posted Date: 2022-07-06

Last Posted Date: 2022-11-25

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 113

Registration Number: NCT05444556

Locations: 🇺🇸
Altasciences Clinical Los Angeles, Inc, Cypress, California, United States
🇺🇸
Qps-Mra, Llc, South Miami, Florida, United States
🇺🇸
ICON Early Phase Services, San Antonio, Texas, United States

Drug-Drug Interaction Study Between EDP-514, Itraconazole, Carbamazepine, and Quinidine in Healthy Subjects

Phase 1

Completed

Conditions: Hepatitis B

Interventions: Drug: EDP-514
Drug: Quinidine
Drug: Carbamazepin
Drug: Itraconazole

First Posted Date: 2021-03-05

Last Posted Date: 2021-08-16

Lead Sponsor: Enanta Pharmaceuticals, Inc

Target Recruit Count: 72

Registration Number: NCT04783753

Locations: 🇺🇸
Pharmaceutical Research Association, Lenexa, Kansas, United States

Drug-Drug Interaction Study Between EDP-938, Itraconazole, Rifampin, and Quinidine in Healthy Subjects

Phase 1

Completed

Conditions: RSV Infection

Interventions: Drug: EDP-938
Drug: Itraconazole
Drug: Rifampin
Drug: Quinidine

First Posted Date: 2018-11-28

Last Posted Date: 2019-06-14

Lead Sponsor: Enanta Pharmaceuticals, Inc

Target Recruit Count: 72

Registration Number: NCT03755778

Locations: 🇺🇸
Pharmaceutical Research Associates, Inc.,, Lenexa, Kansas, United States

Drug-drug Interaction Study Between EDP-305, Fluconazole and Quinidine in Healthy Volunteers

Phase 1

Completed

Conditions: NASH - Nonalcoholic Steatohepatitis

Interventions: Drug: Fluconazole
Drug: Quinidine
Drug: EDP-305

First Posted Date: 2018-08-01

Last Posted Date: 2018-12-05

Lead Sponsor: Enanta Pharmaceuticals, Inc

Target Recruit Count: 48

Registration Number: NCT03610945

Locations: 🇺🇸
Pharmaceutical Research Associates, Inc.,, Salt Lake City, Utah, United States

Safety and Pharmacokinetics of Quinidine Alone and in Combination With Dabigatran Etexilate

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: dabigatran etexilate
Drug: quinidine

First Posted Date: 2014-06-24

Last Posted Date: 2014-06-24

Lead Sponsor: Boehringer Ingelheim

Target Recruit Count: 42

Registration Number: NCT02171624

Clinical Trial Nuedexta in Subjects With ALS

Phase 2

Completed

Conditions: Amyotrophic Lateral Sclerosis (ALS)

Interventions: Drug: Nuedexta
Drug: Matching Placebo

First Posted Date: 2013-03-07

Last Posted Date: 2017-03-24

Lead Sponsor: Center for Neurologic Study, La Jolla, California,

Target Recruit Count: 90

Registration Number: NCT01806857

Locations: 🇺🇸
Neurology Associates, P.C., Lincoln, Nebraska, United States
🇺🇸
California Pacific Medical Center, San Francisco, California, United States
🇺🇸
The Cleveland Clinic, Cleveland, Ohio, United States

and more 4 locations

Drug Development Updates

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