Glucosamine

Generic Name: Glucosamine

Drug Type: Small Molecule

Chemical Formula: C_₆H_₁₃NO_₅

CAS Number: 3416-24-8

Unique Ingredient Identifier: N08U5BOQ1K

Background: Osteoarthritis (OA) is a progressive and degenerative joint disease marked by loss of cartilage, bone changes, and synovial membrane inflammation. Treatment with chondroprotective drugs, such as glucosamine sulfate may offer additional benefits to nonsteroidal anti-inflammatory drugs treating the painful symptoms of OA. Glucosamine is commonly used over the counter as a treatment for arthritic joint pain, although its acceptance as a medical therapy varies due to contradictory and findings with unclear clinical significance during clinical trials. It is currently not approved as a prescription product by the FDA, but is widely available over the counter.

Indication: Glucosamine is generally used over the counter in the symptomatic treatment of osteoarthritis and joint pain, frequently combined with chondroitin sulfate and/or ibuprofen.

Associated Conditions: Back pain, Joint Pain, Osteoarthritis (OA), Osteoarthritis of the Knee, Articular inflammation

Clinical Trials

Study of Association of Anti-inflammatory and Anti-rheumatic

Phase 3

Conditions: Osteoarthritis

Interventions: Drug: Meloxicam and Glucosamine
Drug: Meloxicam
Drug: Glucosamine

First Posted Date: 2015-05-19

Last Posted Date: 2015-05-19

Lead Sponsor: Zodiac Produtos Farmaceuticos S.A.

Target Recruit Count: 375

Registration Number: NCT02448199

Effect of Glucosamine on Intraocular Pressure

Phase 3

Conditions: Intraocular Pressure Changes After Glucosamine Sulfate Consumption.

Interventions: Drug: Placebo three times a day
Drug: glucosamine sulfate 1500 mg three times a day

First Posted Date: 2014-12-03

Last Posted Date: 2015-05-08

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Target Recruit Count: 41

Registration Number: NCT02306083

Locations: 🇮🇷
Islamic Republic OF Iran, Tehran, Iran, Islamic Republic of

Glucosamine Periodontal Adjunctive Therapy

Early Phase 1

Terminated

Conditions: Chronic Periodontitis

Interventions: Drug: lactose capsules
Drug: glucosamine sulphate

First Posted Date: 2014-08-12

Last Posted Date: 2014-08-12

Lead Sponsor: Ain Shams University

Target Recruit Count: 40

Registration Number: NCT02214095

Locations: 🇪🇬
Ainshams University, Cairo, Egypt

A Clinical Study of Xin'an Medicine in the Treatment of Knee Osteoarthritis

Not Applicable

Completed

Conditions: Knee Osteoarthritis

Interventions: Drug: Xinfeng capsule
Drug: glucosamine sulfate

First Posted Date: 2014-06-19

Last Posted Date: 2015-08-20

Lead Sponsor: The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine

Target Recruit Count: 268

Registration Number: NCT02167516

Locations: 🇨🇳
the First Affiliated Hospital of Anhui University of Chinese Medicine, HeFei, Anhui, China
🇨🇳
The Taihe County Hospital of Chinese Medicine, Taihe, Anhui, China
🇨🇳
The Tianchang City Hospital of Chinese Medicine, Tianchang, Anhui, China

Efficacy and Safety of Glucosamine Sulfate and Chondroitin Sulfate Combination in Treatment of Knee Osteoarthritis

Phase 3

Completed

Conditions: Knee Osteoarthritis

Interventions: Drug: glucosamine sulfate /chondroitin sulfate - capsules
Drug: glucosamine sulfate /chondroitin sulfate - sachet
Drug: Cosamin DS®

First Posted Date: 2013-12-13

Last Posted Date: 2013-12-13

Lead Sponsor: Ache Laboratorios Farmaceuticos S.A.

Target Recruit Count: 922

Registration Number: NCT02010918

Locations: 🇧🇷
Serviço de reumatologia do hospital e maternidade celso pierro da PUC-Campinas, Campinas, São Paulo, Brazil

Clinical Efficacy of Glucosamine Plus Diacerein Versus Mono-therapy of Glucosamine

Phase 4

Completed

Conditions: Diacerein
Osteoarthritis
Glucosamine

Interventions: Drug: Glucosamine sulfate
Drug: Placebo (for Diacerein)
Drug: Diacerein

First Posted Date: 2013-07-24

Last Posted Date: 2017-05-30

Lead Sponsor: Ramathibodi Hospital

Target Recruit Count: 148

Registration Number: NCT01906801

Locations: 🇹🇭
Department of Orthopaedics, Faculty of Medicine Ramathibodi Hospital, Bangkok, Mahidol University, Bangkok, Thailand

Non-inferiority Study of the Glucosamine Sulfate + Chondroitin Sulfate Association Capsule in Comparison to the CONDROFLEX® Product in Osteoarthrosis of the Knee

Phase 3

Conditions: Osteoarthritis, Knee

Interventions: Drug: Glucosamine sulfate + chondroitin sulfate - MANTECORP
Drug: Glucosamine sulfate + chondroitin sulfate - CONDROFLEX

First Posted Date: 2010-07-29

Last Posted Date: 2010-07-29

Lead Sponsor: Mantecorp Industria Quimica e Farmaceutica Ltd.

Target Recruit Count: 250

Registration Number: NCT01172249

Efficacy and Safety Study of Glucosamine/Chondroitin Sulfate to Patients Treatment With Osteoarthrosis of the Knee

Phase 3

Completed

Conditions: Osteoarthritis of the Knee

Interventions: Drug: Glucosamine sulphate and chondroitin sulphate association
Drug: Cosamin DS® (Nutramax)

First Posted Date: 2009-08-10

Last Posted Date: 2023-02-08

Lead Sponsor: Eurofarma Laboratorios S.A.

Target Recruit Count: 100

Registration Number: NCT00955552

Locations: 🇧🇷
Centro Paulista de Investigacoes Clinicas Ltda, Sao Paulo, Brazil
🇧🇷
Instituto de Medicina Avancada, Sao Paulo, Brazil
🇧🇷
Centro de Pesquisa Clínica Perdizes, Sao Paulo, Brazil

and more 1 locations