Levetiracetam

Generic Name
Levetiracetam
Brand Names
Elepsia, Keppra, Matever, Roweepra, Spritam, Levetiracetam Accord, Levetiracetam Teva, Levetiracetam Actavis, Levetiracetam ratiopharm, Levetiracetam Sun, Levetiracetam Actavis Group, Levetiracetam Hospira
Drug Type
Small Molecule
Chemical Formula
C8H14N2O2
CAS Number
102767-28-2
Unique Ingredient Identifier
44YRR34555
Background

Levetiracetam is a drug within the pyrrolidine class that is used to treat various types of seizures stemming from epileptic disorders. It was first approved for use in the United States in 1999 and is structurally and mechanistically unrelated to other anti-epileptic drugs (AEDs). Levetiracetam possesses a wide therapeutic index and little-to-no potential t...

Indication

Levetiracetam is indicated as an adjunctive therapy in the treatment of partial onset seizures in epileptic patients who are one month of age and older. Additionally, it is indicated as an adjunct in the treatment of myoclonic seizures in patients with juvenile myoclonic epilepsy who are 12 years of age and older, and in primary generalized tonic-clonic seiz...

Associated Conditions
Epilepsies, Generalized Tonic-Clonic Seizures, Partial-Onset Seizures, Myoclonic seizures
Associated Therapies
-
Clinical Trials
Related News

Keppra IV for the Treatment of Motor Fluctuations in Parkinson's Disease

Phase 4
Withdrawn
Conditions
Parkinson's Disease
Interventions
Drug: levetiracetam
Drug: Placebo
First Posted Date
2008-01-02
Last Posted Date
2021-11-16
Lead Sponsor
University of South Florida
Registration Number
NCT00584025
Locations
🇺🇸

University of South Florida, Tampa, Florida, United States

Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients

First Posted Date
2007-12-19
Last Posted Date
2018-01-17
Lead Sponsor
Yale University
Target Recruit Count
28
Registration Number
NCT00577005
Locations
🇺🇸

VA CT Healthcare System, West Haven, Connecticut, United States

Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery

Phase 4
Completed
Conditions
Epilepsy
Primary Brain Tumor
Interventions
Drug: levetiracetam
First Posted Date
2007-12-11
Last Posted Date
2009-08-20
Lead Sponsor
University Hospital Tuebingen
Target Recruit Count
30
Registration Number
NCT00571155
Locations
🇩🇪

University Hospital Tuebingen, Department of General Neurology, Tuebingen, Baden-Wuerttemberg, Germany

Levetiracetam in the Management of Bipolar Depression

Not Applicable
Completed
Conditions
Bipolar Depression
Interventions
Drug: Placebo
Drug: Levetiracetam
First Posted Date
2007-12-03
Last Posted Date
2020-03-31
Lead Sponsor
Yale University
Target Recruit Count
35
Registration Number
NCT00566150
Locations
🇺🇸

Yale University School of Medicine, New Haven, Connecticut, United States

Prevention of Post-traumatic Seizures With Levetiracetam

Phase 3
Terminated
Conditions
Epilepsy, Post-Traumatic
Interventions
Drug: Levetiracetam
Drug: Placebo
First Posted Date
2007-11-30
Last Posted Date
2012-06-21
Lead Sponsor
Rennes University Hospital
Target Recruit Count
23
Registration Number
NCT00566046
Locations
🇫🇷

Explorations Fonctionnelles Neurologiques - CHU Nantes, Rennes, France

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Neurophysiologie Clinique - CHU Lille, Lille, France

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Neurology - CHU Bordeaux, Bordeaux, France

and more 12 locations

Carisbamate Retention Study (CaReS): Comparative Study on the Long Term Effectiveness, Safety and Tolerability of Carisbamate Compared to Two Other Frequently Prescribed Anti-epileptic Drugs (AEDs) in Patients With Epilepsy.

First Posted Date
2007-11-26
Last Posted Date
2013-01-29
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SK Life Science, Inc.
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89
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Pharmacokinetic Study of Levetiracetam in Epileptic Pediatric Subjects Ranging in Age From 1 Month to Less Than 4 Years Old

Phase 2
Completed
Conditions
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First Posted Date
2007-10-16
Last Posted Date
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13
Registration Number
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A Safety and Efficacy Follow-up Study With Levetiracetam in Children (4-17 Years Old) Suffering From Absence Seizures

Phase 2
Completed
Conditions
Absence Seizures
First Posted Date
2007-10-16
Last Posted Date
2013-09-17
Lead Sponsor
UCB Pharma
Target Recruit Count
4
Registration Number
NCT00545012

Levetiracetam Versus Carbamazepine in Post-Stroke Late Onset Crisis

First Posted Date
2007-10-12
Last Posted Date
2008-05-30
Lead Sponsor
Scienze Neurologiche Ospedaliere
Target Recruit Count
630
Registration Number
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Ospedale Civico, Palermo, Italy

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Ospedale S. Giacomo, Novi Ligure, AL, Italy

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Ospedale S. Croce E Carle, Cuneo, CN, Italy

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Pregabalin Versus Levetiracetam In Partial Seizures

Phase 3
Completed
Conditions
Partial Seizures
Interventions
Drug: pregabalin
Drug: levetiracetam
First Posted Date
2007-10-01
Last Posted Date
2021-01-28
Lead Sponsor
Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Target Recruit Count
509
Registration Number
NCT00537238
Locations
🇻🇪

Pfizer Investigational Site, Caracas, Miranda, Venezuela

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