Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
-

Morphine Versus Ketorolac in Low Back Pain

Phase 4
Conditions
Interventions
First Posted Date
2016-05-25
Last Posted Date
2016-05-25
Lead Sponsor
Loredana Ghinea
Target Recruit Count
100
Registration Number
NCT02782286

Morphine Versus Ketorolac in Renal Colic

Phase 4
Conditions
Interventions
First Posted Date
2016-05-25
Last Posted Date
2016-05-25
Lead Sponsor
Loredana Ghinea
Target Recruit Count
100
Registration Number
NCT02782273

Atropine in Laparoscopic Gynaecological Surgery

First Posted Date
2016-05-11
Last Posted Date
2016-05-11
Lead Sponsor
Clinica Santa Maria
Target Recruit Count
150
Registration Number
NCT02769325
Locations
🇨🇱

Clinica Santa Maria, Santiago, Chile

Tolerability and Toxicity of Topically Applied Nepafenac 0.3% vs Ketorolac 0.5%

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2016-04-27
Last Posted Date
2017-03-07
Lead Sponsor
MDbackline, LLC
Target Recruit Count
200
Registration Number
NCT02752646
Locations
🇺🇸

Cincinnati Eye Institute, Edgewood, Kentucky, United States

🇺🇸

Harvard Eye Associates, Laguna Hills, California, United States

Preoperative Ketorolac for Pain Control in Scleral Buckle Surgery

First Posted Date
2016-04-06
Last Posted Date
2016-09-22
Lead Sponsor
Sun Yat-sen University
Target Recruit Count
73
Registration Number
NCT02729285
Locations
🇨🇳

Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China

Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes

First Posted Date
2016-03-07
Last Posted Date
2023-07-10
Lead Sponsor
Hospital for Special Surgery, New York
Target Recruit Count
178
Registration Number
NCT02700451
Locations
🇺🇸

Hospital for Special Surgery, New York, New York, United States

Psoas Compartment Block Versus Periarticular Local Anesthetic for Total Hip Arthroplasty

First Posted Date
2016-01-18
Last Posted Date
2018-05-09
Lead Sponsor
William Beaumont Hospitals
Target Recruit Count
100
Registration Number
NCT02658149
Locations
🇺🇸

Beaumont Hospital, Royal Oak, Michigan, United States

Ketorolac Sublingual vs. Fentanyl Intranasal in Pain Control for Bilateral Myringotomy and Tubes (BMT) Placement in Children

First Posted Date
2016-01-12
Last Posted Date
2021-09-13
Lead Sponsor
Anica Crnkovic
Target Recruit Count
150
Registration Number
NCT02653742
Locations
🇺🇸

Albany Medical Center, Albany, New York, United States

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