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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

A Comparison of Naropin and Ketorolac for Postoperative Analgesia After Total Knee Arthroplasty

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
Drug: Saline
First Posted Date
2009-03-25
Last Posted Date
2014-03-10
Lead Sponsor
University of Aarhus
Target Recruit Count
60
Registration Number
NCT00868348
Locations
🇩🇰

Aarhus University, Aarhus, Denmark

Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

Phase 4
Conditions
Pain
Interventions
First Posted Date
2009-03-25
Last Posted Date
2009-03-26
Lead Sponsor
Santa Casa de Misericordia de Santos
Target Recruit Count
40
Registration Number
NCT00869219
Locations
🇧🇷

Santa Casa de Misericordia de Santos, Santos, Sao Paulo, Brazil

Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies

First Posted Date
2009-03-19
Last Posted Date
2011-05-24
Lead Sponsor
Clinica Oftamologica Zona Sul
Target Recruit Count
30
Registration Number
NCT00865540
Locations
🇧🇷

Clínica Oftalmológica Zona Sul, Recife, Pernambuco, Brazil

Post-Operative Treatment With Ketorolac After Abdominal Myomectomy

Not Applicable
Completed
Conditions
Febrile Morbidity
Pain
Interventions
Drug: saline
First Posted Date
2009-02-18
Last Posted Date
2009-02-18
Lead Sponsor
Ascher-Walsh, Charles, M.D.
Target Recruit Count
112
Registration Number
NCT00845754
Locations
🇺🇸

Columbia University Medical Center, New York, New York, United States

Local Infiltration Analgesia Following Total Knee Arthroplasty

Not Applicable
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2008-11-27
Last Posted Date
2008-11-27
Lead Sponsor
Region Örebro County
Target Recruit Count
48
Registration Number
NCT00799175
Locations
🇸🇪

University Hospital Orebro, Orebro, Sweden

Efficacy of Ketorolac 0.4% in Prostaglandin Suppression

Phase 4
Completed
Conditions
Inflammation
Interventions
Drug: Lubricating Eye Drop
First Posted Date
2008-11-14
Last Posted Date
2011-09-23
Lead Sponsor
Allergan
Target Recruit Count
9
Registration Number
NCT00791323

Modulation of Remifentanil-induced Postinfusion Hyperalgesia

Phase 4
Completed
Conditions
Hyperalgesia, Secondary
Interventions
First Posted Date
2008-11-05
Last Posted Date
2011-07-01
Lead Sponsor
Ullevaal University Hospital
Target Recruit Count
16
Registration Number
NCT00785863
Locations
🇳🇴

Ullevaal University Hospital, Oslo, Norway

Intravenous Ketorolac for Postoperative Pain in Percutaneous Nephrolithotomy

Phase 4
Completed
Conditions
Renal Calculus
Kidney Stones
Interventions
Drug: Placebo
First Posted Date
2008-10-02
Last Posted Date
2012-01-27
Lead Sponsor
Mayo Clinic
Target Recruit Count
17
Registration Number
NCT00765128
Locations
🇺🇸

Mayo Clinic, Phoenix, Arizona, United States

Intravenous Ketorolac for Postoperative Pain in Laparoscopic Donor Nephrectomy

Phase 4
Completed
Conditions
Nephrectomy
Laparoscopic Donor Nephrectomy
Interventions
Drug: Placebo
First Posted Date
2008-10-02
Last Posted Date
2012-01-27
Lead Sponsor
Mayo Clinic
Target Recruit Count
111
Registration Number
NCT00765232
Locations
🇺🇸

Mayo Clinic, Phoenix, Arizona, United States

Exploratory Study of OMS302 Injection in Subjects Undergoing Unilateral Cataract Extraction by Phacoemulsification.

Phase 1
Completed
Conditions
Cataract Extraction
Interventions
Drug: OMS302-PE
Drug: Vehicle
First Posted Date
2008-07-24
Last Posted Date
2014-07-18
Lead Sponsor
Omeros Corporation
Target Recruit Count
60
Registration Number
NCT00721695
Locations
🇺🇸

Shasta Eye Medical Group, Redding, California, United States

🇺🇸

Davis Duehr Dean, Madison, Wisconsin, United States

🇺🇸

Silverstein Eye Centers, Kansas City, Missouri, United States

and more 1 locations
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