MedPath

Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

A Pilot Clinical Trial of a New Neuromodulation Device for Acute Attacks of Migraine in Children and Adolescents

Phase 3
Completed
Conditions
Migraine Disorders
Interventions
Device: Active Remote Electrical Neuromodulation Device
Drug: Placebo
Device: Sham Remote Electrical Neuromodulation Device
First Posted Date
2021-11-01
Last Posted Date
2025-03-12
Lead Sponsor
University of Calgary
Target Recruit Count
22
Registration Number
NCT05102591
Locations
🇨🇦

Alberta Children's Hospital, Calgary, Alberta, Canada

Effectiveness of Premedication on the Success Rate of Inferior Alveolar Nerve Block

Not Applicable
Completed
Conditions
Symptomatic Irreversible Pulpitis
Interventions
First Posted Date
2021-10-28
Last Posted Date
2022-02-14
Lead Sponsor
Alfarabi Colleges
Target Recruit Count
250
Registration Number
NCT05097768
Locations
🇸🇦

Vission Colleges, Jeddah, Saudi Arabia

Ketorolac on Postoperative Pain Reduction in Pediatric Patients with Adenotonsillectomy

Phase 4
Completed
Conditions
Sleep-Disordered Breathing
Obstructive Sleep Apnea
Adenotonsillar Hypertrophy
Acute Post Operative Pain
Interventions
First Posted Date
2021-10-12
Last Posted Date
2025-02-03
Lead Sponsor
St. Louis University
Target Recruit Count
142
Registration Number
NCT05074056
Locations
🇺🇸

SSM Cardinal Glennon Children's Hospital, Saint Louis, Missouri, United States

Pain Control Following Total Hip Arthroplasty

First Posted Date
2021-09-30
Last Posted Date
2024-08-16
Lead Sponsor
St. Mary's Research Center, Canada
Target Recruit Count
240
Registration Number
NCT05062356
Locations
🇨🇦

St. Mary's Hospital Center, Montréal, Quebec, Canada

Ketorolac vs Oxycodone for Great Toe Arthrodesis

Phase 1
Recruiting
Conditions
Arthrodesis
Interventions
First Posted Date
2021-09-23
Last Posted Date
2023-07-12
Lead Sponsor
Medstar Health Research Institute
Target Recruit Count
40
Registration Number
NCT05054868
Locations
🇺🇸

Amy Loveland, Baltimore, Maryland, United States

Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy

Phase 2
Withdrawn
Conditions
Radical Prostatectomies
Interventions
First Posted Date
2021-06-25
Last Posted Date
2022-09-06
Lead Sponsor
Wake Forest University Health Sciences
Registration Number
NCT04939987
Locations
🇺🇸

Wake Forest Health Sciences, Winston-Salem, North Carolina, United States

Effectiveness of Corticosteroid vs Ketorolac Shoulder Injections

Phase 4
Withdrawn
Conditions
Rotator Cuff Tendinitis
Full-thickness Rotator Cuff Tear
Interventions
First Posted Date
2021-05-20
Last Posted Date
2024-11-15
Lead Sponsor
Michael Khazzam
Target Recruit Count
400
Registration Number
NCT04895280
Locations
🇺🇸

University of Texas Southwestern Medical Center, Dallas, Texas, United States

Effect of Postoperative Ketorolac on Bone Healing After Joint Fusion

Phase 3
Conditions
Ketorolac
Joint Fusion
Interventions
Procedure: great toe (1st metatarsophalangeal joint) fusion
Drug: 5/325mg Oxycodone-Acetaminophen
First Posted Date
2021-05-04
Last Posted Date
2021-05-04
Lead Sponsor
Rothman Institute Orthopaedics
Target Recruit Count
140
Registration Number
NCT04872283
Locations
🇺🇸

Rothman Orthopaedic Institute, Philadelphia, Pennsylvania, United States

Ketorolac in Palatoplasty

Phase 4
Recruiting
Conditions
Cleft Lip and Palate
Interventions
Drug: Placebo
First Posted Date
2021-02-25
Last Posted Date
2023-12-11
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
74
Registration Number
NCT04771156
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study

Completed
Conditions
Hammertoe
Bunion of Unspecified Foot
Ankle Fractures
Achilles Tendon Surgery
Bunionette of Unspecified Foot
Interventions
First Posted Date
2021-02-25
Last Posted Date
2023-04-27
Lead Sponsor
Prisma Health-Midlands
Target Recruit Count
72
Registration Number
NCT04771741
Locations
🇺🇸

Prisma Health Midlands, Columbia, South Carolina, United States

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