Rocuronium

Generic Name
Rocuronium
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C32H53N2O4
CAS Number
143558-00-3
Unique Ingredient Identifier
WRE554RFEZ
Background

Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, rocuronium has rapid onset, and intermediate duration of action. It is commonly marketed under the trade names Zemuron and Esmeron. The drug is associated with the risk of developing allergic reactions in some high-risk patients, such as those with asthma. However, there was a similar incidence of allergic reactions associated with other non-depolarizing neuromuscular blocking agents. Sugammadex is a γ-cyclodextrin derivative that has been introduced as a novel agent to reverse the action of rocuronium.

Indication

For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions
Muscle fasciculation caused by succinylcholine
Associated Therapies
Curarization therapy, Neuromuscular blocking therapy, Facilitation of small bowel intubation therapy

Neuromuscular Blockade for Post-Cardiac Arrest Care

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-10-09
Last Posted Date
2021-01-29
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
83
Registration Number
NCT02260258
Locations
🇺🇸

Brigham and Women's Hospital, Boston, Massachusetts, United States

🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

🇺🇸

Robert Swor, Royal Oak, Michigan, United States

and more 2 locations

Mask Ventilation Before and After Neuromuscular Blockade

First Posted Date
2014-09-11
Last Posted Date
2015-04-09
Lead Sponsor
University of Washington
Target Recruit Count
210
Registration Number
NCT02237443
Locations
🇺🇸

Harborview Medical Center, Seattle, Washington, United States

Interaction of Statins and Nondepolarizing Muscle Relaxants

Conditions
Interventions
First Posted Date
2014-08-21
Last Posted Date
2014-10-23
Lead Sponsor
Huang-wei LV
Target Recruit Count
60
Registration Number
NCT02222519
Locations
🇨🇳

China Medical University, Shenyang, Liaoning, China

Effect of Laparoscopic Operation on Rocuronium and Cisatracurium: Pharmacokinetic and Pharmacodynamic Analysis

First Posted Date
2014-07-18
Last Posted Date
2020-08-12
Lead Sponsor
Fudan University
Target Recruit Count
100
Registration Number
NCT02194855

Effects of Deep Neuromuscular Blockade on Intraoperative Respiratory Mechanics

First Posted Date
2014-07-09
Last Posted Date
2016-07-25
Lead Sponsor
Seoul St. Mary's Hospital
Target Recruit Count
61
Registration Number
NCT02185339
Locations
🇰🇷

Seoul St. Mary's Hospital, Seoul, Korea, Republic of

A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning

Phase 2
Completed
Conditions
Interventions
First Posted Date
2014-05-26
Last Posted Date
2016-11-17
Lead Sponsor
University of Edinburgh
Target Recruit Count
45
Registration Number
NCT02147054
Locations
🇱🇰

Peradeniya Teaching Hospital, Peradeniya, Central Province, Sri Lanka

Laparoscopic Bariatric Surgery: Impact of Deep Neuromuscular Block on Surgical Conditions

First Posted Date
2014-04-21
Last Posted Date
2015-07-30
Lead Sponsor
Central Hospital, Nancy, France
Target Recruit Count
92
Registration Number
NCT02118844
Locations
🇫🇷

CHU Nancy/Brabois, Vandoeuvre-Les-Nancy, France

The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy

First Posted Date
2014-04-09
Last Posted Date
2015-06-24
Lead Sponsor
Yonsei University
Target Recruit Count
67
Registration Number
NCT02109133
Locations
🇰🇷

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

Validation of Subjective Rating Scales Used to Assess Surgical Conditions in Abdominal Surgery

First Posted Date
2014-03-05
Last Posted Date
2014-07-09
Lead Sponsor
Herlev Hospital
Target Recruit Count
14
Registration Number
NCT02079337
Locations
🇩🇰

Department of minimal invasive gynecology Aleris-Hamlet Private Hospital, Søborg, Denmark

Supported Ventilation in ARDS Patients

First Posted Date
2014-02-17
Last Posted Date
2014-12-02
Lead Sponsor
University Medical Center Nijmegen
Target Recruit Count
12
Registration Number
NCT02064140
Locations
🇳🇱

Radboud university medical center, Nijmegen, Netherlands

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