Rocuronium

Generic Name: Rocuronium

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₃₂H_₅₃N_₂O_₄

CAS Number: 143558-00-3

Unique Ingredient Identifier: WRE554RFEZ

Background: Rocuronium (rapid onset-curonium) is a desacetoxy analogue of vecuronium with a more rapid onset of action. It is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia, to facilitate endotracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Introduced in 1994, ro...

Indication: For inpatients and outpatients as an adjunct to general anesthesia to facilitate both rapid sequence and routine tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation.

Associated Conditions: Muscle fasciculation caused by succinylcholine

Associated Therapies: Curarization therapy, Neuromuscular blocking therapy, Facilitation of small bowel intubation therapy

Clinical Trials

Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery

Phase 4

Completed

Conditions: Chronic Kidney Disease
Prostate Cancer
Endometriosis
Fibroids
Bowel Obstruction
Cholecystitis
Uterine Prolapse

Interventions: Procedure: Deep to Moderate NMB
Procedure: Moderate to Deep NMB
Drug: Rocuronium

First Posted Date: 2016-06-24

Last Posted Date: 2020-04-08

Lead Sponsor: Stony Brook University

Target Recruit Count: 79

Registration Number: NCT02812186

Locations: 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States

Comparison of Onset and Duration of Rocuronium Between 2nd Trimester Pregnant and Non-pregnant Women

Completed

Conditions: Pregnancy

Interventions: Drug: Rocuronium

First Posted Date: 2016-06-14

Last Posted Date: 2019-02-27

Lead Sponsor: Hallym University Kangnam Sacred Heart Hospital

Target Recruit Count: 90

Registration Number: NCT02797860

Locations: 🇰🇷
Kangnam sacred heart hospital, Seoul, Yeongdeungpo-gu, Korea, Republic of

Continuous NMB in PCAS

Phase 2

Completed

Conditions: Out-of-hospital Cardiac Arrest

Interventions: Drug: Esmeron
Drug: Saline

First Posted Date: 2016-06-03

Last Posted Date: 2016-12-07

Lead Sponsor: Chun Song Youn

Target Recruit Count: 81

Registration Number: NCT02790164

Locations: 🇰🇷
Seoul St. Mary's Hospital, Seoul, Korea, Republic of

Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium

Phase 4

Completed

Conditions: Muscle Relaxation Caused by Sevoflurane

Interventions: Drug: Sevoflurane
Drug: Rocuronium

First Posted Date: 2016-05-30

Last Posted Date: 2016-06-09

Lead Sponsor: Maharashtra University of Health Sciences

Target Recruit Count: 60

Registration Number: NCT02785653

Locations: 🇮🇳
Jaslok Hospital and Research Centre, Mumbai, Maharastra, India

Atropine in Laparoscopic Gynaecological Surgery

Phase 4

Conditions: Gynecology
Laparoscopic Surgery

Interventions: Drug: Placebo
Drug: Atropine
Drug: Sevoflurane
Drug: sugammadex
Drug: Ketorolac
Drug: Morphine PCA
Drug: rocuronium
Drug: propofol

First Posted Date: 2016-05-11

Last Posted Date: 2016-05-11

Lead Sponsor: Clinica Santa Maria

Target Recruit Count: 150

Registration Number: NCT02769325

Locations: 🇨🇱
Clinica Santa Maria, Santiago, Chile

Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Not Applicable

Completed

Conditions: Neuromuscular Monitoring

Interventions: Drug: MAC 0.75
Drug: MAC 1.0
Drug: MAC 0.5
Drug: Propofol
Drug: Etomidate
Drug: Rocuronium

First Posted Date: 2016-03-17

Last Posted Date: 2016-03-17

Lead Sponsor: Tianjin Medical University General Hospital

Target Recruit Count: 175

Registration Number: NCT02711917

The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia

Phase 4

Completed

Conditions: Anesthesia
Neuromuscular Blockade

Interventions: Drug: Propofol
Drug: Remifentanil
Drug: Rocuronium

First Posted Date: 2016-03-16

Last Posted Date: 2016-07-12

Lead Sponsor: Ankara University

Target Recruit Count: 84

Registration Number: NCT02709473

Locations: 🇹🇷
Ankara University, Ankara, Turkey
🇹🇷
Harran University, Sanliurfa, Turkey

Surgical Conditions During Laparoscopic Bariatric Surgery

Phase 4

Completed

Conditions: Morbid Obesity

Interventions: Drug: Rocuronium
Device: Insufflation pressure

First Posted Date: 2016-03-09

Last Posted Date: 2018-06-21

Lead Sponsor: University of Missouri-Columbia

Target Recruit Count: 144

Registration Number: NCT02703909

Locations: 🇺🇸
University Hospital, Columbia, Missouri, United States

Recovery of Muscle Function After Deep Neuromuscular Block by Means of Diaphragm Ultrasonography

Phase 4

Conditions: Post-operative Residual Curarization

Interventions: Drug: Sugammadex
Device: Diaphragm Ultrasonography
Drug: Neostigmine
Device: Neurumuscual monitoring
Drug: Atropine
Drug: Rocuronium
Drug: Fentanyl
Drug: Propofol
Drug: Sevoflurane

First Posted Date: 2016-03-04

Last Posted Date: 2016-10-25

Lead Sponsor: University of Florence

Target Recruit Count: 58

Registration Number: NCT02698969

Locations: 🇮🇹
Azienda Ospdaliero Universitaria Careggi, Florence, Italy

Pediatric Inguinal Hernia Repair: Are Muscle Relaxants Necessary? Endotracheal Intubation vs Laryngeal Mask Airway

Not Applicable

Completed

Conditions: Inguinal Hernia
Endotracheal Intubation
Laryngeal Mask
Muscle Relaxants

Interventions: Device: Proseal LMA
Device: ETT
Other: No Muscle Relaxant
Drug: Rocuronium

First Posted Date: 2016-03-02

Last Posted Date: 2016-06-01

Lead Sponsor: Maltepe University

Target Recruit Count: 80

Registration Number: NCT02696837

Locations: 🇹🇷
Maltepe University Hospital, Istanbul, Turkey

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