Aspirin

Generic Name: Aspirin

Brand Names: Aggrenox, Alka-seltzer, Alka-seltzer Fruit Chews, Anacin, Arthriten Inflammatory Pain, Ascomp, Aspi-cor, Aspir-low, Bayer Aspirin, Bayer Womens, Bc Arthritis, Bc Original Formula, Bufferin, Duoplavin, Durlaza, Ecotrin, Ecpirin, Endodan Reformulated May 2009, Equagesic, Exaprin, Excedrin, Excedrin PM Triple Action, Fasprin, Fiorinal, Goody's Body Pain, Goody's Extra Strength, Goody's PM, Miniprin, Norgesic, Norgesic Forte, Orphengesic, Pamprin Max Formula, Robaxisal, ST. Joseph Aspirin, Stanback Headache Powder Reformulated Jan 2011, Trianal, Trianal C, Vanquish, Vazalore, Yosprala

Drug Type: Small Molecule

Chemical Formula: C_₉H_₈O_₄

CAS Number: 50-78-2

Unique Ingredient Identifier: R16CO5Y76E

Background: Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) .
...

Indication: Pain, fever, and inflammation
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Associated Conditions: Acute Coronary Syndrome (ACS), Anxiety, Atherothrombotic cerebral infarction, Cardiovascular Disease (CVD), Cardiovascular Events, Cardiovascular Mortality, Colorectal Adenomas, Colorectal Cancer, Common Cold, Coronary artery reocclusion, Death, Dyspeptic signs and symptoms, Fever, Flu caused by Influenza, Headache, Heterozygous Familial Hypercholesterolemia (HeFH), Inflammation, Juvenile Idiopathic Arthritis (JIA), Major Adverse Cardiovascular and Cerebrovascular Events (MACCE), Menstrual Pain, Migraine, Morbidity, Mucocutaneous Lymph Node Syndrome, Muscle Contraction, Myalgia, Myocardial Infarction, Myocardial Infarction (MI), first occurrence, Neuropathic Pain, Pain, Pain caused by Common Cold, Pain caused by Rheumatism, Pericarditis, Polycythemia Vera (PV), Pre-Eclampsia, Rheumatism, Rheumatoid Arthritis, Rhino Sinusitis, Severe Pain, Spondyloarthropathies, Stroke, Systemic Lupus Erythematosus, Tension Headache, Thromboembolism, Thrombosis, Toothache, Transient Ischemic Attack, Vascular Death, Venous Thromboembolism, Acute Inflammation, Articular inflammation, Atherothrombotic events, Death caused by Myocardial Infarction, Fever or influenza-like illness, Moderate Pain, Recurrent Ischemic Stroke

Associated Therapies: Anti-platelet Therapy, Hemodialysis Treatment, Secondary Prevention

Clinical Trials

Trial of Aspirin and Arginine Restriction in Colorectal Cancer

Phase 2

Completed

Conditions: Colorectal Cancer

Interventions: Drug: Aspirin

First Posted Date: 2007-12-21

Last Posted Date: 2023-07-07

Lead Sponsor: University of California, Irvine

Target Recruit Count: 24

Registration Number: NCT00578721

Locations: 🇺🇸
Chao Family Comprehensive Cancer Center, Orange, California, United States

Does Aspirin Have a Protective Role Against Chemotherapeutically Induced Ototoxicity?

Not Applicable

Conditions: Hearing Loss
Ototoxicity

Interventions: Drug: placebo
Drug: aspirin

First Posted Date: 2007-12-21

Last Posted Date: 2007-12-21

Lead Sponsor: University Health Network, Toronto

Target Recruit Count: 110

Registration Number: NCT00578760

Locations: 🇨🇦
Princess Margaret Hospital, Toronto, Ontario, Canada

Effect of Apple Flavanols on Risk of Cardiovascular Disease

Not Applicable

Completed

Conditions: Cardiovascular Disease

Interventions: Dietary Supplement: Low PA apple puree
Dietary Supplement: High PA apple puree
Drug: Aspirin

First Posted Date: 2007-12-05

Last Posted Date: 2013-03-06

Lead Sponsor: Quadram Institute Bioscience

Target Recruit Count: 26

Registration Number: NCT00568152

Locations: 🇬🇧
Institue of Food Research, Norwich, Norfolk, United Kingdom

Aspirin for Dukes C and High Risk Dukes B Colorectal Cancers

Phase 3

Active, not recruiting

Conditions: Colorectal Cancer

Interventions: Other: placebo
Drug: Acetylsalicylic acid

First Posted Date: 2007-11-30

Last Posted Date: 2024-02-02

Lead Sponsor: National Cancer Centre, Singapore

Target Recruit Count: 1587

Registration Number: NCT00565708

Locations: 🇦🇺
Macarthur Cancer Therapy Centre, Campbelltown, New South Wales, Australia
🇦🇺
Chris O'Brien Lifehouse, Clinical Research Centre, Camperdown, New South Wales, Australia
🇦🇺
Coffs Harbour Health Campus North Coast Cancer Institute, Coffs Harbour, New South Wales, Australia

and more 64 locations

Laboratory Aspirin Resistance in Diabetics and Non-Diabetics

Not Applicable

Completed

Conditions: Drug Resistance

First Posted Date: 2007-11-26

Last Posted Date: 2008-06-10

Lead Sponsor: University of Aarhus

Target Recruit Count: 210

Registration Number: NCT00563875

Locations: 🇩🇰
Department of Clinical Biochemistry, Centre for Haemophilia and Thrombosis, Aarhus University Hospital Skejby, Aarhus N, Denmark

Patent Foramen Ovale Closure or Anticoagulants Versus Antiplatelet Therapy to Prevent Stroke Recurrence

Phase 3

Completed

Conditions: Ischemic Stroke
Patent Foramen Ovale
Atrial Septal Aneurysm
Migraine

Interventions: Drug: aspirin
Drug: Antivitamins K or rivaroxaban or dabigatran or apixaban
Device: Devices for PFO closure

First Posted Date: 2007-11-22

Last Posted Date: 2017-10-19

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 664

Registration Number: NCT00562289

Locations: 🇫🇷
Hôpital Saint-Anne, Paris, France

Platelet Function and Safety After IV and Oral Diclofenac, IV Ketorolac and Oral Aspirin in Adult Volunteers

Phase 1

Completed

Conditions: Healthy

Interventions: Drug: aspirin
Drug: oral diclofenac (Cataflam)
Drug: intravenous diclofenac sodium (DIC075V)
Drug: ketorolac

First Posted Date: 2007-10-24

Last Posted Date: 2008-07-16

Lead Sponsor: Javelin Pharmaceuticals

Target Recruit Count: 30

Registration Number: NCT00548678

Locations: 🇺🇸
Comprehensive Phase One, Miramar, Florida, United States

Nephropathy In Type 2 Diabetes and Cardio-renal Events

Phase 4

Completed

Conditions: Diabetic Nephropathy

Interventions: Drug: SoC therapy
Drug: irbesartan
Drug: ramipril
Drug: hydrochlorothiazide
Drug: furosemide
Drug: amlodipine
Drug: atenolol
Drug: doxazosin
Drug: clonidine
Drug: insulin
Drug: simvastatin
Drug: fibrate
Drug: erythropoietin
Drug: aspirin

First Posted Date: 2007-09-27

Last Posted Date: 2020-08-03

Lead Sponsor: University of Campania "Luigi Vanvitelli"

Target Recruit Count: 850

Registration Number: NCT00535925

Locations: 🇮🇹
Department of Advanced Medical and Surgical Sciences, Università della Campania "Luigi Vanvitelli", Naples, Italy, Naples, Italy

Aspirin in Patients With Myocardial Infarction and Thrombocytopenia

Phase 3

Terminated

Conditions: Thrombocytopenia
Myocardial Infarction

Interventions: Drug: Aspirin

First Posted Date: 2007-07-16

Last Posted Date: 2012-08-01

Lead Sponsor: M.D. Anderson Cancer Center

Target Recruit Count: 5

Registration Number: NCT00501345

Locations: 🇺🇸
U.T.M.D. Anderson Cancer Center, Houston, Texas, United States

A Phase III Study of Apixaban in Patients With Atrial Fibrillation

Phase 3

Completed

Conditions: Atrial Fibrillation

Interventions: Drug: Apixaban
Drug: Acetylsalicylic acid

First Posted Date: 2007-07-04

Last Posted Date: 2018-06-15

Lead Sponsor: Bristol-Myers Squibb

Target Recruit Count: 6421

Registration Number: NCT00496769

Locations: 🇺🇸
Stamford Therapeutics Consortium, Stamford, Connecticut, United States
🇺🇸
Kaiser Permanente Medical Center, West Los Angeles, Los Angeles, California, United States
🇺🇸
Southwest Heart, Tucson, Arizona, United States

and more 65 locations

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