Phenylephrine

Generic Name: Phenylephrine

Brand Names: 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₂

CAS Number: 59-42-7

Unique Ingredient Identifier: 1WS297W6MV

Background: Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication: Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.

Associated Conditions: Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Clinical Trials

Vasopressor Impact on Brain Circulation, Organ Blood Flow and Tissue Oxygenation During Anesthesia

Phase 2

Recruiting

Conditions: Hypotension

Interventions: Drug: Noradrenalin
Drug: Phenylephrine

First Posted Date: 2023-10-16

Last Posted Date: 2024-12-17

Lead Sponsor: University of Aarhus

Target Recruit Count: 32

Registration Number: NCT06083948

Locations: 🇩🇰
Aarhus University Hospital, Aarhus, Denmark

Vasopressor Outcomes in Spine Surgery

Early Phase 1

Recruiting

Conditions: Hypotension

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2023-09-25

Last Posted Date: 2025-01-03

Lead Sponsor: University of Texas Southwestern Medical Center

Target Recruit Count: 120

Registration Number: NCT06053398

Locations: 🇺🇸
Clements University Hospital at Dallas, Dallas, Texas, United States

Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences

Phase 4

Suspended

Conditions: Vasoconstriction
Vasodilation

Interventions: Drug: Norepinephrine Bitartrate
Drug: Phenylephrine Hydrochloride
Drug: Phentolamine Mesylate
Drug: Propranolol Hydrochloride
Drug: Isoproterenol Hydrochloride

First Posted Date: 2023-08-18

Last Posted Date: 2024-10-09

Lead Sponsor: University of Alberta

Target Recruit Count: 30

Registration Number: NCT05997732

Locations: 🇨🇦
University of Alberta, Edmonton, Alberta, Canada

Cerebral Flow-metabolism Coupling During Adult Surgery

Phase 4

Recruiting

Conditions: Anesthesia

Interventions: Drug: Propofol
Drug: Sevoflurane
Drug: Phenylephrine
Drug: Ephedrine

First Posted Date: 2023-07-12

Last Posted Date: 2023-10-18

Lead Sponsor: Jason Chui

Target Recruit Count: 80

Registration Number: NCT05941494

Locations: 🇨🇦
London Health Sciences Centre, London, Ontario, Canada

Epinephrine Infusion for Prophylaxis Against Maternal Hypotension After Spinal Anesthesia for Cesarean Delivery

Not Applicable

Completed

Conditions: Hypotension During Surgery

Interventions: Drug: Phenylephrine
Drug: Epinephrine

First Posted Date: 2023-05-31

Last Posted Date: 2024-02-28

Lead Sponsor: Cairo University

Target Recruit Count: 196

Registration Number: NCT05881915

Locations: 🇪🇬
Yasmin Ibrahim, Cairo, Egypt

Effects of Vasopressors on Cerebral Hemodynamics in Patients with Carotid Endarterectomy (TCD Part)

Not Applicable

Completed

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-12-27

Last Posted Date: 2024-11-05

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 90

Registration Number: NCT05665881

Locations: 🇨🇳
Beijing Tiantan Hospital, Capital Medical University, Beijing, China

Sex Differences in Sympathetic Vascular Reactivity at High Altitude

Not Applicable

Completed

Conditions: Vasodilation
Vasoconstriction

Interventions: Drug: Sodium Nitroprusside
Drug: Phenylephrine Hydrochloride
Drug: Norepinephrine
Other: Isometric Handgrip and Post-Exercise Circulatory Occlusion
Other: Rhythmic Handgrip
Other: Cold Pressor Test
Drug: Propranolol Hydrochloride
Drug: Phentolamine Mesylate

First Posted Date: 2022-09-01

Last Posted Date: 2023-03-23

Lead Sponsor: University of Alberta

Target Recruit Count: 17

Registration Number: NCT05525416

Locations: 🇨🇦
University of Alberta, Edmonton, Alberta, Canada
🇨🇦
University of British Columbia - Okanagan, Kelowna, British Columbia, Canada

The Effect of Epinephrine, Norepinephrine and Phenylephrine on Intraoperative Hemodynamic Performance

Phase 4

Recruiting

Conditions: Cardiac Output, Low
Cardiac Output, High
Perfusion; Complications

Interventions: Drug: Epinephrin
Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2022-08-09

Last Posted Date: 2022-10-19

Lead Sponsor: Medical University of Vienna

Target Recruit Count: 225

Registration Number: NCT05492968

Locations: 🇦🇹
Medical University of Vienna, Vienna, Austria

Management of Acute Pulmonary Hypertensive Crisis in Children With Known Pulmonary Arterial Hypertension

Phase 4

Completed

Conditions: Pulmonary Arterial Hypertension

Interventions: Drug: Arginine Vasopressin
Drug: Phenylephrine
Drug: Epinephrine

First Posted Date: 2022-06-30

Last Posted Date: 2022-08-05

Lead Sponsor: Stanford University

Target Recruit Count: 15

Registration Number: NCT05439460

Locations: 🇺🇸
Cardiac Catheterization Lab,Stanford University Medical Center, Stanford, California, United States

Effects of Vasopressors on Cerebral Hemodynamics in Patients With Carotid Endarterectomy (MRI Part)

Not Applicable

Not yet recruiting

Conditions: Carotid Endarterectomy

Interventions: Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2022-06-10

Last Posted Date: 2023-08-24

Lead Sponsor: Beijing Tiantan Hospital

Target Recruit Count: 60

Registration Number: NCT05414877

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