Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation ...
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Efficacy and Safety of the Combination of Acetylcysteine, Paracetamol and Phenylephrine for the Treatment of Common Cold
- Conditions
- Interventions
- First Posted Date
- 2021-10-07
- Last Posted Date
- 2024-08-07
- Lead Sponsor
- Sandoz
- Target Recruit Count
- 1002
- Registration Number
- NCT05070650
Effects of Vasopressor on the Graft Blood Flow in TRAM
- Conditions
- Interventions
- First Posted Date
- 2021-09-20
- Last Posted Date
- 2023-05-03
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT05049278
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
- First Posted Date
- 2021-09-05
- Last Posted Date
- 2023-01-05
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT05035888
- Locations
- 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
Prophylactic Norepinephrine and Phenylephrine Infusion for Hemodynamic Effects in Patients With Preeclampsia
- Conditions
- Interventions
- First Posted Date
- 2021-09-05
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 72
- Registration Number
- NCT05035498
- Locations
- 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
The Potency of Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
- First Posted Date
- 2021-09-05
- Last Posted Date
- 2021-09-13
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 80
- Registration Number
- NCT05035472
Maternal Cardiac Output Response to Rescue Norepinephrine and Phenylephrine Boluses in Patients With Severe Preeclampsia
- Conditions
- Interventions
- First Posted Date
- 2021-09-05
- Last Posted Date
- 2024-02-02
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Target Recruit Count
- 40
- Registration Number
- NCT05035485
- Locations
- 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China
Phenylephrine and Pulse Pressure Variability
- Conditions
- Interventions
- First Posted Date
- 2021-08-18
- Last Posted Date
- 2024-08-22
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 8
- Registration Number
- NCT05011357
- Locations
- 🇺🇸
Texas Health Resources, Dallas, Texas, United States
Sex Differences in Sympathetic Activity and Vascular Reactivity During Acute and Chronic Hypoxia.
- Conditions
- Interventions
- First Posted Date
- 2021-08-11
- Last Posted Date
- 2022-10-31
- Lead Sponsor
- University of Alberta
- Target Recruit Count
- 14
- Registration Number
- NCT05001048
- Locations
- 🇨🇦
University of Alberta, Edmonton, Alberta, Canada
🇨🇦Mount Royal University, Calgary, Alberta, Canada
Effect of Three Weight-adjusted Vasopressors for Elective Cesarean Delivery
- Conditions
- Interventions
- First Posted Date
- 2021-08-05
- Last Posted Date
- 2021-12-30
- Lead Sponsor
- Xuzhou Medical University
- Target Recruit Count
- 78
- Registration Number
- NCT04991662
- Locations
- 🇨🇳
Department of Anesthesiology and Operating Room, Affiliated Hospital of Peking University People's Hospital, Peking, Beijing, China
GUARDIAN (NCT04884802) Sub-study, Phenylephrine v. Norepinephrine
- First Posted Date
- 2021-06-22
- Last Posted Date
- 2023-08-30
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 6254
- Registration Number
- NCT04934748
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.