Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation ...
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Evaluation of Patients After Cardiac Surgery: Novel Ultrasound Parameters for Quantification of Renal Perfusion & Analysis of Phenylephrines' Effect on Invasive Haemodynamics and Echocardiographic Measures
- First Posted Date
- 2020-06-05
- Last Posted Date
- 2021-08-06
- Lead Sponsor
- Aarhus University Hospital
- Target Recruit Count
- 30
- Registration Number
- NCT04419662
- Locations
- 🇩🇰
Aarhus University Hospital, Department of Anaesthesiology, Aarhus, Denmark
Norepinephrine for Hypotension in Cesarean Section
- Conditions
- Interventions
- First Posted Date
- 2020-04-29
- Last Posted Date
- 2023-01-04
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 180
- Registration Number
- NCT04367103
- Locations
- 🇪🇬
Assiut University, Assiut, Egypt
Blood PREssure Augmentation in Large-vessel Occlusion Stroke Study
- Conditions
- Interventions
- First Posted Date
- 2020-01-06
- Last Posted Date
- 2024-10-03
- Lead Sponsor
- Yale University
- Target Recruit Count
- 40
- Registration Number
- NCT04218773
- Locations
- 🇺🇸
Yale-New Haven Hospital, New Haven, Connecticut, United States
The Effect of Vasopressors on Cerebral Oxygentaion During Off Pump CABG
- Conditions
- Interventions
- First Posted Date
- 2020-01-02
- Last Posted Date
- 2022-05-09
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 90
- Registration Number
- NCT04214145
- Locations
- 🇰🇷
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
Norepinephrine Versus Phenylephrine for Preventing Spinal Anesthesia Induced Hypotension in Elderly
- Conditions
- Interventions
- First Posted Date
- 2019-12-11
- Last Posted Date
- 2021-09-01
- Lead Sponsor
- Kasr El Aini Hospital
- Target Recruit Count
- 62
- Registration Number
- NCT04195321
- Locations
- 🇪🇬
Kasr Alaini Hospital, Cairo, Egypt
Noradrenaline Infusion Versus Phenylephrine Infusion in Improving Serum Lactate Level in HIPEC
- Conditions
- Interventions
- First Posted Date
- 2019-10-30
- Last Posted Date
- 2024-05-29
- Lead Sponsor
- Suez Canal University
- Target Recruit Count
- 30
- Registration Number
- NCT04144465
- Locations
- 🇪🇬
Suez Canal University, Ismailia, Egypt
Intraoperative Phenylephrine Infusion to Reduce Postoperative Shivering in Lower Segment Caesarean Section
- Conditions
- Interventions
- First Posted Date
- 2019-10-21
- Last Posted Date
- 2020-07-08
- Lead Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
- Target Recruit Count
- 118
- Registration Number
- NCT04133961
- Locations
- 🇲🇾
Pusat Perubatan Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Methylene Blue as a Third-line Vasopressor in Septic Shock
- First Posted Date
- 2019-09-13
- Last Posted Date
- 2022-07-26
- Lead Sponsor
- Carilion Clinic
- Target Recruit Count
- 250
- Registration Number
- NCT04089072
- Locations
- 🇺🇸
Carilion Clinic, Roanoke, Virginia, United States
Norepinephrine and Phenylephrine, Which Better for Elderly?
- First Posted Date
- 2019-08-28
- Last Posted Date
- 2019-10-08
- Target Recruit Count
- 100
- Registration Number
- NCT04067817
- Locations
- 🇨🇳
The Second Hospital of Dalian Medical University, Dalian, Liaoning, China
Effects of Ephedrine, Phenylephrine, Norepinephrine and Vasopressin on Contractility of Human Myometrium and Umbilical Vessels: An In-vitro Study
- Conditions
- Interventions
- First Posted Date
- 2019-08-12
- Last Posted Date
- 2024-03-07
- Target Recruit Count
- 144
- Registration Number
- NCT04053478
- Locations
- 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada
Drug Development Updates
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