Phenylephrine

Generic Name
Phenylephrine
Brand Names
4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
Drug Type
Small Molecule
Chemical Formula
C9H13NO2
CAS Number
59-42-7
Unique Ingredient Identifier
1WS297W6MV
Background

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication

Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation ...

Associated Conditions
Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
Associated Therapies
Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Effect of Changing Physiological Conditions on Myogenic Oscillations: Pilot Study

First Posted Date
2018-10-25
Last Posted Date
2022-06-30
Lead Sponsor
University of California, San Francisco
Target Recruit Count
40
Registration Number
NCT03719001
Locations
🇺🇸

University of California San Francisco, San Francisco, California, United States

Development of Advanced Double Intravenous Vasopressor Automated (ADIVA) System

First Posted Date
2018-08-08
Last Posted Date
2024-10-09
Lead Sponsor
KK Women's and Children's Hospital
Target Recruit Count
173
Registration Number
NCT03620942
Locations
🇸🇬

KK Women's and Children's Hospital, Singapore, Singapore

Preventive Intramuscular Phenylephrine in Elective Cesarean Section Under Spinal Anesthesia

First Posted Date
2018-04-25
Last Posted Date
2019-07-05
Lead Sponsor
Xuzhou Medical University
Target Recruit Count
99
Registration Number
NCT03507387
Locations
🇨🇳

The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

Norepinephrine Versus Phenylephrine Continuous Variable Infusion in Cesarean Delivery

First Posted Date
2017-11-01
Last Posted Date
2018-07-17
Lead Sponsor
Cairo University
Target Recruit Count
123
Registration Number
NCT03328533
Locations
🇪🇬

Cairo University, Cairo, Egypt

Vasopressor Infusion in Cesarean Delivery

First Posted Date
2017-08-14
Last Posted Date
2021-09-27
Lead Sponsor
Cairo University
Target Recruit Count
120
Registration Number
NCT03248791
Locations
🇪🇬

Cairo University, Cairo, Egypt

Phenylephrine or Norepinephrine for a Better Hemodynamic Stability

First Posted Date
2017-07-12
Last Posted Date
2018-01-23
Lead Sponsor
The Second Affiliated Hospital of Dalian Medical University
Target Recruit Count
40
Registration Number
NCT03215797

Effect of Vasopressors on Spinal Anaesthesia Induced Hypotension

First Posted Date
2017-05-23
Last Posted Date
2019-10-24
Lead Sponsor
Cukurova University
Target Recruit Count
160
Registration Number
NCT03163914
Locations
🇹🇷

Çukurova University Balcalı Hospital, Adana, Turkey

The Effect of Brimonidine on Intraocular Pressure When Dilating Routine Patients

First Posted Date
2017-05-04
Last Posted Date
2018-08-09
Lead Sponsor
Wake Forest University Health Sciences
Target Recruit Count
5
Registration Number
NCT03139708
Locations
🇺🇸

Wake Forest Baptist Health Eye Center, Winston-Salem, North Carolina, United States

Ephedrine and Phenylephrine for Spinal Hypotension

Phase 2
Completed
Conditions
Interventions
First Posted Date
2017-02-08
Last Posted Date
2020-10-27
Lead Sponsor
Assiut University
Target Recruit Count
60
Registration Number
NCT03047109
Locations
🇪🇬

Assiut university hospital, Assiut, Egypt

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