Phenylephrine

Generic Name: Phenylephrine

Brand Names: 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₂

CAS Number: 59-42-7

Unique Ingredient Identifier: 1WS297W6MV

Background: Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication: Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.

Associated Conditions: Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Clinical Trials

Phenylephrine and Noradrenaline for Post Spinal Anesthesia Hypotension

Phase 2

Completed

Conditions: Adverse Anesthesia Outcome

Interventions: Drug: phenylephrine
Drug: Norepinephrine
Drug: Bupivacaine
Drug: Fentanyl
Drug: Placebo (normal saline)

First Posted Date: 2017-01-10

Last Posted Date: 2017-05-03

Lead Sponsor: Kasr El Aini Hospital

Target Recruit Count: 200

Registration Number: NCT03015857

Effectiveness of Phenylefrine in Prevention of Hypotension During Spinal Anesthesia for Cesarean Delivery

Phase 4

Completed

Conditions: Hypotension Drug-Induced

Interventions: Drug: Phenylephrine

First Posted Date: 2016-12-01

Last Posted Date: 2017-02-24

Lead Sponsor: Universidad Industrial de Santander

Target Recruit Count: 140

Registration Number: NCT02979405

Locations: 🇨🇴
Clinic materno infaltil San Luis, Bucaramanga, Santander, Colombia

Norepinephrine and Phenylephrine for Maternal Cardiac Output During Spinal Anesthesia for Elective Cesarean Delivery

Phase 4

Conditions: Hypotension

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2016-11-21

Last Posted Date: 2017-03-10

Lead Sponsor: Jeju National University Hospital

Target Recruit Count: 50

Registration Number: NCT02969239

Locations: 🇰🇷
Jeju National University Hospital, Jeju, Korea, Republic of

A Comparison of Intermittent Intravenous Boluses of Phenylephrine and Norepinephrine to Prevent Spinal-induced Hypotension in Cesarean Deliveries

Not Applicable

Completed

Conditions: Hypotension

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2016-11-15

Last Posted Date: 2017-05-24

Lead Sponsor: Samuel Lunenfeld Research Institute, Mount Sinai Hospital

Target Recruit Count: 112

Registration Number: NCT02962986

Locations: 🇨🇦
Mount Sinai Hospital, Toronto, Ontario, Canada

Phenylephrine and Hypotension During Spinal Anesthesia for Cesarean Section

Phase 2

Completed

Conditions: Anesthesia, Spinal
Anesthesia, Obstetrical

Interventions: Other: Placebo
Drug: Phenylephrine

First Posted Date: 2016-11-08

Last Posted Date: 2017-05-18

Lead Sponsor: Assiut University

Target Recruit Count: 980

Registration Number: NCT02958215

Locations: 🇪🇬
Faculty of Medicine, Assiut, Egypt

Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C

Phase 4

Completed

Conditions: Septic Shock

Interventions: Drug: Recombinant Activated Protein C
Device: Near-infrared spectroscopy (NIRS)
Drug: Phenylephrine
Biological: Blood sample

First Posted Date: 2016-08-31

Last Posted Date: 2016-08-31

Lead Sponsor: Central Hospital, Nancy, France

Target Recruit Count: 30

Registration Number: NCT02885168

Effect of High vs. Low MAP Levels on Clinical Outcomes in Elderly Patients During Noncardiothoracic Surgery

Not Applicable

Conditions: Surgery
Postoperative Delirium
Anesthesia
Blood Loss, Surgical
Aging
Blood Pressure

Interventions: Drug: Urapidil
Drug: Phenylephrine
Procedure: Low-level MAP
Procedure: High-level MAP

First Posted Date: 2016-08-05

Last Posted Date: 2016-08-16

Lead Sponsor: Hu Anmin

Target Recruit Count: 322

Registration Number: NCT02857153

Locations: 🇨🇳
West China Hospital affiliated to Sichuan University, Chengdu, Sichuan, China
🇨🇳
The Third Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
🇨🇳
Shenzhen People's Hospital, Shenzhen, Guangdong, China

and more 4 locations