Phenylephrine

Generic Name: Phenylephrine

Brand Names: 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₂

CAS Number: 59-42-7

Unique Ingredient Identifier: 1WS297W6MV

Background: Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication: Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.

Associated Conditions: Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Clinical Trials

Detecting Hypotension By Continuous Non-invasive Arterial Pressure Monitoring

Not Applicable

Conditions: Hypotension

Interventions: Drug: phenylephrine

First Posted Date: 2015-08-25

Last Posted Date: 2015-11-09

Lead Sponsor: Fudan University

Target Recruit Count: 100

Registration Number: NCT02532270

Locations: 🇨🇳
Department of Anesthesiology, Department of Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China

Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly

Phase 2

Suspended

Conditions: Post-operative Cognitive Dysfunction

Interventions: Procedure: Hemodynamic target
Drug: Phenylephrine
Drug: Intravenous fluids
Procedure: Patient's positioning
Procedure: Reduction of depth of anesthesia
Drug: Ephedrine
Drug: Epinephrine
Drug: Norepinephrine
Drug: Dopamine

First Posted Date: 2015-04-28

Last Posted Date: 2018-04-13

Lead Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Target Recruit Count: 1812

Registration Number: NCT02428062

Locations: 🇮🇹
Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico; Via F. Sforza 35, Milano, Italy

Descemet Endothelial Thickness Comparison Trial

Phase 4

Conditions: Keratoplasty
Grafting, Corneal
Transplantation, Cornea
Keratoplasty, Lamellar
Transplantation, Corneal

Interventions: Procedure: DSAEK
Procedure: DMEK
Device: Endoserter
Drug: Prednisolone
Drug: Ofloxacin
Drug: Tropicamide
Device: Jones Tube
Drug: Phenylephrine

First Posted Date: 2015-02-26

Last Posted Date: 2020-11-25

Lead Sponsor: Oregon Health and Science University

Target Recruit Count: 38

Registration Number: NCT02373137

Locations: 🇺🇸
Byers Eye Institute, Stanford University, Palo Alto, California, United States
🇺🇸
F. I. Proctor Foundation, University of California, San Francisco, San Francisco, California, United States
🇺🇸
Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, United States

Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean Delivery

Phase 4

Completed

Conditions: Effects of; Anesthesia, in Labor and Delivery

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2015-02-03

Last Posted Date: 2017-01-04

Lead Sponsor: West Virginia University

Target Recruit Count: 85

Registration Number: NCT02354833

Locations: 🇺🇸
West Virginia University Hospital, Morgantown, West Virginia, United States

Study to Determine the Pharmacokinetics and Pharmacodynamic Effects of Phenylephrine on BP Via IV

Phase 4

Recruiting

Conditions: Hypotension

Interventions: Drug: Phenylephrine

First Posted Date: 2014-12-23

Last Posted Date: 2024-07-23

Lead Sponsor: West-Ward Pharmaceutical

Target Recruit Count: 100

Registration Number: NCT02323399

Locations: 🇺🇸
Children's Healthcare of Atlanta at Egleston, Atlanta, Georgia, United States
🇺🇸
Children's Medical Center of Dallas, Dallas, Texas, United States
🇺🇸
Stony Brook Medicine, Stony Brook, New York, United States

and more 7 locations